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  • El Farissi, MohamedDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)

A randomised trial of selective intracoronary hypothermia during primary PCI

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • European Society of Cardiology,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-114307
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-114307URI
  • https://doi.org/10.4244/EIJ-D-23-01042DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: While experimental data suggest that selective intracoronary hypothermia decreases infarct size, studies in patients with ST-elevation myocardial infarction (STEMI) are lacking.AIMS: We investigated the efficacy of selective intracoronary hypothermia during primary percutaneous coronary intervention (PCI) to decrease infarct size in patients with STEMI.METHODS: In this multicentre randomised controlled trial, 200 patients with large anterior wall STEMI were randomised 1:1 to selective intracoronary hypothermia during primary PCI or primary PCI alone. Using an over-the-wire balloon catheter for infusion of cold saline and a pressure-temperature wire to monitor the intracoronary temperature, the anterior myocardium distal to the occlusion was selectively cooled to 30-33°C for 7-10 minutes before reperfusion (occlusion phase), immediately followed by 10 minutes of cooling after reperfusion (reperfusion phase). The primary endpoint was infarct size as a percentage of left ventricular mass on cardiovascular magnetic resonance imaging after 3 months.RESULTS: Selective intracoronary hypothermia was performed in 94/100 patients randomised to cooling. Distal coronary temperature decreased by 6°C within 43 seconds (interquartile range [IQR] 18-113). The median duration of the occlusion phase and reperfusion phase were 8.2 minutes (IQR 7.2-9.0) and 9.1 minutes (IQR 8.2-10.0), respectively. The infarct size at 3 months was 23.1±12.5% in the selective intracoronary hypothermia group and 21.6±12.2% in the primary PCI alone group (p=0.43). The left ventricular ejection fraction at 3 months in each group were 49.1±10.2% and 50.1±10.4%, respectively (p=0.53).CONCLUSIONS: Selective intracoronary hypothermia during primary PCI in patients with anterior wall STEMI was feasible and safe but did not decrease infarct size compared with standard primary PCI. (ClinicalTrials.gov: NCT03447834).

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Pijls, Nico H. J.Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Good, RichardDepartment of Cardiology, Golden Jubilee National Hospital, Clydebank, United Kingdom (författare)
  • Engström, ThomasDepartment of Cardiology, Rigshospitalet, Copenhagen, Denmark (författare)
  • Keeble, Thomas R.Department of Cardiology, Essex Cardiothoracic Centre, Basildon, United Kingdom (författare)
  • Beleslin, BrankoDepartment of Cardiology, Clinical Center of Serbia, Belgrade, Serbia (författare)
  • De Bruyne, BernardCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (författare)
  • Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden(Swepub:oru)oft (författare)
  • Erlinge, DavidDepartment of Cardiology, Skåne University Hospital, Clinical Sciences, Lund University, Lund, Sweden (författare)
  • Teeuwen, KoenDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Eerdekens, RobDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Demandt, Jesse P. A.Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Mangion, KennethDepartment of Cardiology, Golden Jubilee National Hospital, Clydebank, United Kingdom (författare)
  • Lonborg, JakobDepartment of Cardiology, Rigshospitalet, Copenhagen, Denmark (författare)
  • Setz-Pels, WikkeDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Karamasis, GrigorisDepartment of Cardiology, Essex Cardiothoracic Centre, Basildon, United Kingdom (författare)
  • Wijnbergen, IngeDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Vlaar, Pieter JanDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • de Vos, AnnemiekDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Brueren, Guus R.Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Oldroyd, KeithDepartment of Cardiology, Golden Jubilee National Hospital, Clydebank, United Kingdom (författare)
  • Berry, ColinDepartment of Cardiology, Golden Jubilee National Hospital, Clydebank, United Kingdom (författare)
  • Tonino, Pim A. L.Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Van't Veer, MarcelDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Otterspoor, Luuk C.Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands (författare)
  • Department of Cardiology, Catharina Hospital, Eindhoven, the NetherlandsDepartment of Cardiology, Golden Jubilee National Hospital, Clydebank, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:EuroIntervention: European Society of Cardiology20:121774-024X1969-6213

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