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Pathophysiology fro...
Pathophysiology from preconception, during pregnancy, and beyond
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- Hivert, Marie-France (author)
- Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA
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- Backman, Helena, 1965- (author)
- Örebro universitet,Institutionen för hälsovetenskaper,Faculty of Medicine and Health, Department of Obstetrics and Gynecology, Örebro University, Örebro, Sweden
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- Benhalima, Katrien (author)
- Endocrinology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
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- Catalano, Patrick (author)
- Maternal Infant Research Institute, Obstetrics and Gynecology Research, Tufts Medical Center, Boston, MA, USA; School of Medicine, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
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- Desoye, Gernot (author)
- Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
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- Immanuel, Jincy (author)
- School of Medicine, Western Sydney University, Sydney, NSW, Australia; Institute for Women's Health, College of Nursing, Texas Woman's University, Denton, TX, USA
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- McKinlay, Christopher J. D. (author)
- Department of Paediatrics Child and Youth Health, University of Auckland, Auckland, New Zealand; Kidz First Neonatal Care, Te Whatu Ora Counties Manukau, Auckland, New Zealand
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- Meek, Claire L. (author)
- Leicester Diabetes Centre, Leicester General Hospital, University of Leicester, Leicester, UK
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- Nolan, Christopher J. (author)
- School of Medicine and Psychology, College of Health and Medicine, Australian National University, Canberra, ACT, Australia; Department of Endocrinology, Canberra Health Services, Woden, ACT, Australia
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- Ram, Uma (author)
- Department of Obstetrics and Gynecology, Seethapathy Clinic and Hospital, Chennai, Tamilnadu, India
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- Sweeting, Arianne (author)
- Department of Endocrinology, Royal Prince Alfred Hospital and University of Sydney, Sydney, NSW, Australia
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- Simmons, David (author)
- School of Medicine, Western Sydney University, Sydney, NSW, Australia
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- Jawerbaum, Alicia (author)
- Facultad de Medicina, Universidad de Buenos Aires (UBA)-CONICET, Buenos Aires, Argentina; Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, Buenos Aires, Argentina
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X.
- Related links:
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https://doi.org/10.1...
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Abstract
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- Gestational diabetes is the most common medical complication in pregnancy. Historically, gestational diabetes was considered a pregnancy complication involving treatment of rising glycaemia late in the second trimester. However, recent evidence challenges this view. Pre-pregnancy and pregnancy-specific factors influence gestational glycaemia, with open questions regarding roles of non-glycaemic factors in the aetiology and consequences of gestational diabetes. Varying patterns of insulin secretion and resistance in early and late pregnancy underlie a heterogeneity of gestational diabetes in the timing and pathophysiological subtypes with clinical implications: early gestational diabetes and insulin resistant gestational diabetes subtypes are associated with a higher risk of pregnancy complications. Metabolic perturbations of early gestational diabetes can affect early placental development, affecting maternal metabolism and fetal development. Fetal hyperinsulinaemia can affect the development of multiple fetal tissues, with short-term and long-term consequences. Pregnancy complications are prevented by managing glycaemia in early and late pregnancy in some, but not all women with gestational diabetes. A better understanding of the pathophysiology and heterogeneity of gestational diabetes will help to develop novel management approaches with focus on improved prevention of maternal and offspring short-term and long-term complications, from pre-conception, throughout pregnancy, and beyond.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Hivert, Marie-Fr ...
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Backman, Helena, ...
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Benhalima, Katri ...
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Catalano, Patric ...
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Desoye, Gernot
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Immanuel, Jincy
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McKinlay, Christ ...
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Meek, Claire L.
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Nolan, Christoph ...
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Ram, Uma
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Sweeting, Ariann ...
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Simmons, David
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Jawerbaum, Alici ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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The Lancet
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Örebro University