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  • Gupta, Shashank,1989-Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark (author)

Environmental shaping of the bacterial and fungal community in infant bed dust and correlations with the airway microbiota

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-08-07
  • BioMed Central (BMC),2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-114664
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-114664URI
  • https://doi.org/10.1186/s40168-020-00895-wDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:Strategiske Forskningsrad (Danish Council for Strategic Research)Ministeriet Sundhed Forebyggelse (Ministry of Health)
  • Background: From early life, children are exposed to a multitude of environmental exposures, which may be of crucial importance for healthy development. Here, the environmental microbiota may be of particular interest as it represents the interface between environmental factors and the child. As infants in modern societies spend a considerable amount of time indoors, we hypothesize that the indoor bed dust microbiota might be an important factor for the child and for the early colonization of the airway microbiome. To explore this hypothesis, we analyzed the influence of environmental exposures on 577 dust samples from the beds of infants together with 542 airway samples from the Copenhagen Prospective Studies on Asthma in Childhood2010 cohort.Results: Both bacterial and fungal community was profiled from the bed dust. Bacterial and fungal diversity in the bed dust was positively correlated with each other. Bacterial bed dust microbiota was influenced by multiple environmental factors, such as type of home (house or apartment), living environment (rural or urban), sex of siblings, and presence of pets (cat and/or dog), whereas fungal bed dust microbiota was majorly influenced by the type of home (house or apartment) and sampling season. We further observed minor correlation between bed dust and airway microbiota compositions among infants. We also analyzed the transfer of microbiota from bed dust to the airway, but we did not find evidence of transfer of individual taxa.Conclusions: Current study explores the influence of environmental factors on bed dust microbiota (both bacterial and fungal) and its correlation with airway microbiota (bacterial) in early life using high-throughput sequencing. Our findings demonstrate that bed dust microbiota is influenced by multiple environmental exposures and could represent an interface between environment and child.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hjelmsø, Mathis H.Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, Copenhagen University Hospital Gentofte, University of Copenhagen, Gentofte, Denmark (author)
  • Lehtimäki, JenniCopenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, Copenhagen University Hospital Gentofte, University of Copenhagen, Gentofte, Denmark (author)
  • Li, XuanjiSection of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark (author)
  • Mortensen, Martin S.Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK (author)
  • Russel, JakobSection of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark (author)
  • Trivedi, UrvishSection of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark (author)
  • Rasmussen, Morten A.Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, Copenhagen University Hospital Gentofte, University of Copenhagen, Gentofte, Denmark; Section of Chemometrics and Analytical Technologies, Department of Food Science, University of Copenhagen, Copenhagen, Denmark (author)
  • Stokholm, JakobCopenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, Copenhagen University Hospital Gentofte, University of Copenhagen, Gentofte, Denmark (author)
  • Bisgaard, HansCopenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, Copenhagen University Hospital Gentofte, University of Copenhagen, Gentofte, Denmark (author)
  • Sørensen, Søren J.Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark (author)
  • Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, DenmarkCopenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, Copenhagen University Hospital Gentofte, University of Copenhagen, Gentofte, Denmark (creator_code:org_t)

Related titles

  • In:Microbiome: BioMed Central (BMC)8:12049-2618

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