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Long-term colectomy...
Long-term colectomy rate after intensive intravenous corticosteroid therapy for ulcerative colitis prior to the immunosuppressive treatment era
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- Gustavsson, Anders (author)
- Örebro universitet,Hälsoakademin,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Halfvarson, Jonas (author)
- Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Magnuson, Anders (author)
- Unit of Statistics and Epidemiology, Center for Clinical Research, Örebro University Hospital, Örebro, Sweden
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- Sandberg-Gertzén, Hanna (author)
- Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Tysk, Curt (author)
- Örebro universitet,Hälsoakademin,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Järnerot, Gunnar (author)
- Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- New York : American College of Gastroenterology, 2007
- 2007
- English.
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In: American Journal of Gastroenterology. - New York : American College of Gastroenterology. - 0002-9270 .- 1572-0241. ; 102:11, s. 2513-2519
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- OBJECTIVES: Corticosteroids are a cornerstone in the treatment of a severe attack of ulcerative colitis (UC). The long-term prognosis in this patient group is not well described. We studied the long-term colectomy and relapse rates in patients given intensive intravenous corticosteroid treatment (IIVT) for acute UC. METHODS: A retrospective clinical study of 158 patients with UC treated in 1975-1982 with IIVT. Patients were followed-up to death, colectomy or last visit. RESULTS: A total of 11 patients were excluded due to change of diagnosis (N = 10) or lost to follow-up (N = 1). The indication for index IIVT in the remaining 147 patients was a severe attack (N = 61), a moderately severe attack (N = 45), a mild attack (N = 29) or chronic continuous disease (N = 12). The median (range) duration of follow-up was 173 (4-271) months in patients escaping colectomy during the first 3 months. Three months after IIVT, the colectomy rates were 28/61 (46%) in a severe attack, 4/45 (9%) in a moderately severe, and 1/29 (3%) in a mild attack. After 10 yr, the colectomy rates were 39/61 (64%), 22/45 (49%), and 8/29 (28%), respectively. During follow-up, neither colectomy incidence beyond 3 months, time to first relapse nor relapse incidence was influenced by severity of initial attack, except for a lower relapse incidence after a severe attack. CONCLUSIONS: In patients escaping colectomy during the first 3 months after IIVT, the future prognosis was similar irrespective of initial disease severity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Gastroenterology
- Gastroenterologi
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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