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  • Jansson, JanetSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology (author)

Metabolomics reveals metabolic biomarkers of Crohn's disease

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-07-28
  • Public Library of Science (PLoS),2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-11989
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11989URI
  • https://doi.org/10.1371/journal.pone.0006386DOI
  • https://res.slu.se/id/publ/26200URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Willing, Ben (author)
  • Lucio, Marianna (author)
  • Fekete, Ages (author)
  • Dicksved, JohanSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology(Swepub:slu)47518 (author)
  • Halfvarson, Jonas (author)
  • Tysk, CurtÖrebro universitet,Hälsoakademin(Swepub:oru)ctk (author)
  • Schmitt-Kopplin, Philippe (author)
  • Sveriges lantbruksuniversitetInstitutionen för mikrobiologi (creator_code:org_t)
  • Sveriges lantbruksuniversitet

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  • In:PloS one: Public Library of Science (PLoS)4:7, s. e6386-1932-6203

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