Search: WFRF:(Kasperzyk Julie L.) >
One-carbon metaboli...
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Kasperzyk, Julie L.
(author)
One-carbon metabolism-related nutrients and prostate cancer survival
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Elsevier BV,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-12068
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-12068URI
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https://doi.org/10.3945/ajcn.2009.27645DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119510168URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Folate and other one-carbon metabolism nutrients may influence prostate cancer pathogenesis. Prior studies of these nutrients in relation to prostate cancer incidence have been inconclusive, and none have explored prostate cancer survival. OBJECTIVE: The objective was to assess whether dietary intakes of folate, riboflavin, vitamin B-6, vitamin B-12, and methionine measured around the time of prostate cancer diagnosis are associated with prostate cancer survival. DESIGN: This population-based prospective study comprised 525 men from Orebro, Sweden, who received a diagnosis of incident prostate cancer between 1989 and 1994 and completed a self-administered food-frequency questionnaire. Record linkages to the Swedish Death Registry enabled all cases to be followed for up to 20 y after diagnosis, and the cause of death was assigned via medical record review. Cox proportional hazards regression was used to calculate multivariable hazard ratios (HRs) and 95% CIs. During a median of 6.4 y of follow-up, 218 men (42%) died of prostate cancer and 257 (49%) of other causes. RESULTS: A comparison of the highest with the lowest quartile showed that vitamin B-6 intake was inversely associated with prostate cancer-specific death (HR: 0.71; 95% CI: 0.46, 1.10; P for trend = 0.08), especially in men with a diagnosis of localized-stage disease (HR; 0.05; 95% CI: 0.01, 0.26; P for trend = 0.0003). However, vitamin B-6 intake was not associated with improved prostate cancer survival among advanced-stage cases (HR: 1.04; 95% CI: 0.64, 1.72; P for trend = 0.87). Folate, riboflavin, vitamin B-12, and methionine intakes were not associated with prostate cancer survival. CONCLUSION: A high vitamin B-6 intake may improve prostate cancer survival among men with a diagnosis of localized-stage disease.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Fall, KatjaKarolinska Institutet(Swepub:oru)kafl
(author)
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Mucci, Lorelei A.
(author)
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Håkansson, NiclasKarolinska Institutet
(author)
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Wolk, AlicjaKarolinska Institutet
(author)
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Johansson, Jan-ErikÖrebro universitet,Hälsoakademin(Swepub:oru)jkjn
(author)
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Andersson, Swen-Olof
(author)
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Andrén, Ove
(author)
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Karolinska InstitutetHälsoakademin
(creator_code:org_t)
Related titles
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In:American Journal of Clinical Nutrition: Elsevier BV90:3, s. 561-5690002-91651938-3207
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