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WFRF:(Kasperzyk Julie L.)
 

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  • Kasperzyk, Julie L. (author)

One-carbon metabolism-related nutrients and prostate cancer survival

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Elsevier BV,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-12068
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-12068URI
  • https://doi.org/10.3945/ajcn.2009.27645DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119510168URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Folate and other one-carbon metabolism nutrients may influence prostate cancer pathogenesis. Prior studies of these nutrients in relation to prostate cancer incidence have been inconclusive, and none have explored prostate cancer survival. OBJECTIVE: The objective was to assess whether dietary intakes of folate, riboflavin, vitamin B-6, vitamin B-12, and methionine measured around the time of prostate cancer diagnosis are associated with prostate cancer survival. DESIGN: This population-based prospective study comprised 525 men from Orebro, Sweden, who received a diagnosis of incident prostate cancer between 1989 and 1994 and completed a self-administered food-frequency questionnaire. Record linkages to the Swedish Death Registry enabled all cases to be followed for up to 20 y after diagnosis, and the cause of death was assigned via medical record review. Cox proportional hazards regression was used to calculate multivariable hazard ratios (HRs) and 95% CIs. During a median of 6.4 y of follow-up, 218 men (42%) died of prostate cancer and 257 (49%) of other causes. RESULTS: A comparison of the highest with the lowest quartile showed that vitamin B-6 intake was inversely associated with prostate cancer-specific death (HR: 0.71; 95% CI: 0.46, 1.10; P for trend = 0.08), especially in men with a diagnosis of localized-stage disease (HR; 0.05; 95% CI: 0.01, 0.26; P for trend = 0.0003). However, vitamin B-6 intake was not associated with improved prostate cancer survival among advanced-stage cases (HR: 1.04; 95% CI: 0.64, 1.72; P for trend = 0.87). Folate, riboflavin, vitamin B-12, and methionine intakes were not associated with prostate cancer survival. CONCLUSION: A high vitamin B-6 intake may improve prostate cancer survival among men with a diagnosis of localized-stage disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fall, KatjaKarolinska Institutet(Swepub:oru)kafl (author)
  • Mucci, Lorelei A. (author)
  • Håkansson, NiclasKarolinska Institutet (author)
  • Wolk, AlicjaKarolinska Institutet (author)
  • Johansson, Jan-ErikÖrebro universitet,Hälsoakademin(Swepub:oru)jkjn (author)
  • Andersson, Swen-Olof (author)
  • Andrén, Ove (author)
  • Karolinska InstitutetHälsoakademin (creator_code:org_t)

Related titles

  • In:American Journal of Clinical Nutrition: Elsevier BV90:3, s. 561-5690002-91651938-3207

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