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Search: WFRF:(Hugot J) > (2005-2009) > TNFSF15 polymorphis...

  • Thiébaut, R.University of Paris (author)

TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-01-13
  • Ovid Technologies (Wolters Kluwer Health),2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-12128
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-12128URI
  • https://doi.org/10.1038/ajg.2008.36DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118305234URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17171URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVES: Inflammatory bowel disease (IBD), e.g., Crohn's disease (CD) and ulcerative colitis (UC), is a complex genetic disorder. Tumor necrosis factor (ligand) superfamily, member 15 (TNFSF15) has been previously identified as a susceptibility gene for CD in Japanese and UK cohorts. This replication study was designed in order to confirm and further validate the role of TNFSF15 in IBD. METHODS: A total of 666 IBD families (corresponding to 2,982 relatives) with European ancestry were genotyped for the rs6478108 and rs7869487 polymorphisms, which define the main TNFSF15 haplotypes previously associated with CD. An association between the main haplotypes and CD, UC and IBD was tested using the Genehunter TDT and Unphased statistics. Caspase recruitment domain 15 (CARD15)/TNFSF15 interaction and genotype/phenotype correlations were also studied. RESULTS: The previously reported "high-risk" haplotype (A) was associated with IBD (P=0.001) (OR=1.25 (1.05-1.50)) and CD (P=0.02) (OR=1.31 (1.03-1.67)) whereas the "protective" (B) haplotype was significantly less transmitted to IBD and CD patients. No interaction between CARD15 and TNFSF15 was detected. We also failed to define a clinical subgroup of CD patients specifically associated with TNFSF15 haplotype A. CONCLUSIONS: This study confirms that TNFSF15 or a closely linked gene is involved in the genetic predisposition to CD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kotti, S.University of Paris (author)
  • Jung, C.University of Paris,Hop Calmette (author)
  • Merlin, F.University of Paris (author)
  • Colombel, J. F. (author)
  • Lemann, M.Hop St Louis (author)
  • Almer, SvenÖstergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)sveal38 (author)
  • Tysk, CurtÖrebro universitet,Hälsoakademin,University of Örebro(Swepub:oru)ctk (author)
  • O'Morain, M.Adelaide & Meath Hospital (author)
  • Gassull, M.Hospital University Germans Trias & Pujol (author)
  • Binder, V.Herlev Hospital (author)
  • Finkel, Y.Karolinska Institutet,Karolinska Children's Hospital (author)
  • Pascoe, L.CEPH, Paris (author)
  • Hugot, J.-P.Hop Robert Debre (author)
  • University of ParisHop Calmette (creator_code:org_t)

Related titles

  • In:American Journal of Gastroenterology: Ovid Technologies (Wolters Kluwer Health)104:2, s. 384-3910002-92701572-0241

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