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IL-1 receptor-assoc...
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Berglund, MartinDept Microbiol & Immunol, Inst Biomed, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden
(författare)
IL-1 receptor-associated kinase M downregulates DSS-induced colitis
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Oxford University Press (OUP),2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-12869
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-12869URI
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https://doi.org/10.1002/ibd.21287DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Ulcerative colitis is associated with increased colon permeability resulting in bacterial translocation into the lamina propria. We investigate the importance of the Toll-like receptor (TLR) regulating protein IL-1 receptor-associated kinase M (IRAK-M) using the erosive dextran sulfate sodium (DSS)-induced model of colitis. Methods: IRAK-M-competent and -incompetent mice were treated with 3% DSS for 5 days followed by 2 days of regular drinking water. Clinical signs of disease were followed for 7 days. At day 7 the mice were sacrificed and plasma and tissue were collected for histopathological examination and analyses of the production of cytokines and chemokines as well as expression of T-cell transcription factors. Results: At day 7 IRAK-M-deficient mice display a reduced total body weight (77.1 +/- 2.1 versus 88.5 +/- 2.0, *P=0.002) and an increased macroscopical (2.7 +/- 0.2 versus 1.6 +/- 0.1, *P 0.002) and histopathological (6.0 +/- 0 versus 3.3 +/- 60.5, *P < 0.001) colon score compared to wildtype mice. Furthermore, IRAK-M-deficient mice have increased colon mRNA expression of proinflammatory cytokines and increased tumor necrosis factor concentrations (41.1 +/- 13.5 versus 12.8 +/- 2.0 pg/mL, *P = 0.010) in plasma. Conclusions: This is the first report examining the role of IRAK-M in colitis. We find that IRAK-M is of critical importance in downregulating induction and progression of DSS colitis, and thereby suggesting that IRAK-M might be a target for future interventional therapies. (Inflamm Bowel Dis 2010; 16: 1778-1786)
Ämnesord och genrebeteckningar
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IRAK-M
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TLR signaling
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colitis
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proinflammatory cytokines
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MEDICINE
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MEDICIN
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Medicine
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Medicin
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Melgar, SilviaAlimentary Pharmabiot Ctr, Univ Coll Cork, Cork, Ireland; Immunoinflammat CEDD GlaxoSmithKline, Stevenage Herts, England
(författare)
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Kobayashi, Koichi S.Harvard Univ, Boston MA, USA
(författare)
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Flavell, Richard A.Yale Univ, New Haven CT, USA
(författare)
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Hultgren Hörnquist, Elisabeth,1965-Örebro universitet,Hälsoakademin(Swepub:oru)eht
(författare)
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Hultgren, Olof H.Department of Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Örebro University Hospital, Örebro, Sweden(Swepub:oru)ovhn
(författare)
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Dept Microbiol & Immunol, Inst Biomed, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, SwedenAlimentary Pharmabiot Ctr, Univ Coll Cork, Cork, Ireland; Immunoinflammat CEDD GlaxoSmithKline, Stevenage Herts, England
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Inflammatory Bowel Diseases: Oxford University Press (OUP)16:10, s. 1778-17861078-09981536-4844
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