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  • Ahrén, MariaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska högskolan (author)

Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-03-24
  • American Chemical Society (ACS),2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-12979
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-12979URI
  • https://doi.org/10.1021/la903566yDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54946URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Recently, much attention has been given to the development of biofunctionalized nanoparticles with magnetic properties for novel biomedical imaging. Guided, smart, targeting nanoparticulate magnetic resonance imaging (MRI) contrast agents inducing high MRI signal will be valuable tools for future tissue specific imaging and investigation of molecular and cellular events. In this study. We report a new design of functionalized ultrasmall rare earth based nanoparticles to be used as a positive contrast agent in NI RI. The relaxivity is compared to commercially available Gd based chelates. The synthesis, PEGylation, and dialysis of small (3-5 nm) gadolinium oxide (DEG-Gd2O3) nanoparticles are presented. The chemical and physical properties of the nanomaterial were investigated with Fourier transform infrared spectroscopy. X-ray photoelectron spectroscopy, transmission electron microscopy, and dynamic light scattering. Neutrophil activation after exposure to this nanomaterial was studied by means of fluorescence microscopy. The proton relaxation times as a function of dialysis time and functionalization were measured at 1.5 T. A capping procedure introducing stabilizing properties was designed and verified, and the dialysis effects were evaluated. A higher proton relaxivity was obtained for as-synthesized diethylene glycol (DEG)-Gd2O3 nanoparticles compared to commercial Gd-DTPA. A slight decrease of the relaxivity for as-synthesized DEG-Gd2O3 nanoparticles as a function of dialysis time was observed. The results for functionalized nanoparticles showed a considerable relaxivity increase for particles dialyzed extensively with r(1) and r(2) values approximately 4 times the corresponding values for Gd-DTPA. The microscopy study showed that PEGylated nanoparticles do not activate neutrophils in contrast to uncapped Gd2O3. Finally, the nanoparticles are equipped with Rhodamine to show that our PEGylated nanoparticles are available for further coupling chemistry, and thus prepared for targeting purposes. The long term goal is to design a powerful, directed contrast agent for MRI examinations with specific targeting possibilities and with properties inducing local contrast, that is. an extremely high MR signal at the cellular and molecular level.

Subject headings and genre

  • MEDICINE
  • MEDICIN
  • Medicine
  • Medicin
  • NATURAL SCIENCES

Added entries (persons, corporate bodies, meetings, titles ...)

  • Selegård, LinnéaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska högskolan(Swepub:liu)linol11 (author)
  • Klasson, AnnaLinköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet(Swepub:liu)annkl89 (author)
  • Söderlind, FredrikLinköpings universitet,Kemi,Tekniska högskolan(Swepub:liu)freso40 (author)
  • Abrikossova, NataliaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska högskolan(Swepub:liu)natab59 (author)
  • Skoglund, CarolineLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)carsk36 (author)
  • Bengtsson, TorbjörnLinköpings universitet,Örebro universitet,Hälsoakademin,Linkoping Univ, Linkoping, Sweden,Avdelningen för läkemedelsforskning,Tekniska högskolan(Swepub:liu)torbe62 (author)
  • Engström, MariaLinköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet(Swepub:liu)maren21 (author)
  • Käll, Per-OlovLinköpings universitet,Kemi,Tekniska högskolan(Swepub:liu)perka28 (author)
  • Uvdal, KajsaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska högskolan(Swepub:liu)kajuv09 (author)
  • Linköpings universitetMolekylär ytfysik och nanovetenskap (creator_code:org_t)

Related titles

  • In:Langmuir: American Chemical Society (ACS)26:8, s. 5753-57620743-74631520-5827

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