Sökning: WFRF:(Troost Freddy) >
Effect of butyrate ...
-
Hamer, Henrike M.Dept Internal Med, Div Gastroenterol Hepatol, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands
(författare)
Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
-
Amsterdam, Netherlands :Elsevier,2010
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:oru-18857
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-18857URI
-
https://doi.org/10.1016/j.clnu.2010.04.002DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Background & Aims: Butyrate, produced by colonic fermentation of dietary fibers is often hypothesized to beneficially affect colonic health. This study aims to assess the effects of butyrate on inflammation and oxidative stress in subjects with chronically mildly elevated parameters of inflammation and oxidative stress.Methods: Thirty-five patients with ulcerative colitis in clinical remission daily administered 60 ml rectal enemas containing WO mM sodium butyrate (n = 17) or saline (n = 18) during 20 days (NCT00696098). Before and after the intervention feces, blood and colonic mucosal biopsies were obtained. Parameters of antioxidant defense and oxidative damage, myeloperoxidase, several cytokines, fecal calprotectin and CRP were determined.Results: Butyrate enemas induced minor effects on colonic inflammation and oxidative stress. Only a significant increase of the colonic IL-10/IL-12 ratio was found within butyrate-treated patients (p = 0.02), and colonic concentrations of CCL5 were increased after butyrate compared to placebo treatment (p = 0.03). Although in general butyrate did not affect colonic glutathione levels, the effects of butyrate enemas on total colonic glutathione appeared to be dependent on the level of inflammation.Conclusion: Although UC patients in remission were characterized by low-grade oxidative stress and inflammation, rectal butyrate enemas showed only minor effects on inflammatory and oxidative stress parameters.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Jonkers, Daisy M. A. E.Dept Internal Med, Div Gastroenterol Hepatol, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands
(författare)
-
Vanhoutvin, Steven A. L. W.Dept Internal Med, Div Gastroenterol Hepatol, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands
(författare)
-
Troost, Freddy J.Dept Internal Med, Div Gastroenterol Hepatol, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands
(författare)
-
Rijkers, GerSt Antonius Hosp, Nieuwegein, Netherlands
(författare)
-
de Bruine, AdriaanDept Pathol, Med Ctr, Maastricht Univ, Maastricht, Netherlands
(författare)
-
Bast, AaltDept Pharmacol & Toxicol, Med Ctr, Maastricht Univ, Maastricht, Netherlands
(författare)
-
Venema, KoenTI Food & Nutr, Wageningen, Netherlands; Dept Biosci, TNO Qual Life, Zeist, Netherlands
(författare)
-
Brummer, RobertÖrebro universitet,Hälsoakademin,Dept Internal Med, Div Gastroenterol Hepatol, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands(Swepub:oru)rnbr
(författare)
-
Dept Internal Med, Div Gastroenterol Hepatol, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, NetherlandsSt Antonius Hosp, Nieuwegein, Netherlands
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Clinical NutritionAmsterdam, Netherlands : Elsevier29:6, s. 738-7440261-56141532-1983
Internetlänk
Hitta via bibliotek
Till lärosätets databas