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Genetic variation i...
Genetic variation in LIN28B is associated with the timing of puberty
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Ong, Ken K. (author)
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Elks, Cathy E. (author)
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Li, Shengxu (author)
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Zhao, Jing Hua (author)
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Luan, Jian'an (author)
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Andersen, Lars B. (author)
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Bingham, Sheila A. (author)
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Brage, Sören (author)
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Smith, George Davey (author)
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- Ekelund, Ulf (author)
- Örebro universitet,Hälsoakademin
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Gillson, Christopher J. (author)
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Glaser, Beate (author)
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Golding, Jean (author)
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Hardy, Rebecca (author)
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Khaw, Kay-Tee (author)
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Kuh, Diana (author)
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Luben, Robert (author)
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Marcus, Michele (author)
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McGeehin, Michael A. (author)
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Ness, Andrew R. (author)
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Northstone, Kate (author)
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Ring, Susan M. (author)
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Rubin, Carol (author)
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Sims, Matthew A. (author)
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Song, Kijoung (author)
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Strachan, David P. (author)
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Vollenweider, Peter (author)
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Waeber, Gerard (author)
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Waterworth, Dawn M. (author)
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Wong, Andrew (author)
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Deloukas, Panagiotis (author)
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Barroso, Ines (author)
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Mooser, Vincent (author)
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Loos, Ruth J. (author)
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Wareham, Nicholas J. (author)
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(creator_code:org_t)
- 2009-05-17
- 2009
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 41:6, s. 729-733
- Related links:
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https://serval.unil....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The timing of puberty is highly variable(1). We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 x 10(-8)). In independent replication studies in 16,373 women, each major allele was associated with 0.12 years earlier menarche (95% CI = 0.08-0.16; P = 2.8 x 10(-10); combined P = 3.6 x 10(-16)). This allele was also associated with earlier breast development in girls (P = 0.001; N = 4,271); earlier voice breaking (P = 0.006, N = 1,026) and more advanced pubic hair development in boys (P = 0.01; N = 4,588); a faster tempo of height growth in girls (P = 0.00008; N = 4,271) and boys (P = 0.03; N = 4,588); and shorter adult height in women (P = 3.6 x 10(-7); N = 17,274) and men (P = 0.006; N = 9,840) in keeping with earlier growth cessation. These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing(2), as the first genetic determinant regulating the timing of human pubertal growth and development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- Sports Science
- Idrottsvetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ong, Ken K.
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Elks, Cathy E.
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Li, Shengxu
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Zhao, Jing Hua
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Luan, Jian'an
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Andersen, Lars B ...
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show more...
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Bingham, Sheila ...
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Brage, Sören
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Smith, George Da ...
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Ekelund, Ulf
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Gillson, Christo ...
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Glaser, Beate
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Golding, Jean
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Hardy, Rebecca
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Khaw, Kay-Tee
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Kuh, Diana
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Luben, Robert
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Marcus, Michele
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McGeehin, Michae ...
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Ness, Andrew R.
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Northstone, Kate
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Ring, Susan M.
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Rubin, Carol
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Sims, Matthew A.
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Song, Kijoung
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Strachan, David ...
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Vollenweider, Pe ...
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Waeber, Gerard
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Waterworth, Dawn ...
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Wong, Andrew
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Deloukas, Panagi ...
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Barroso, Ines
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Mooser, Vincent
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Loos, Ruth J.
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Wareham, Nichola ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
- Articles in the publication
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Nature Genetics
- By the university
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Örebro University