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Subcellular distrib...
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Akner, Gunnar,1953-Örebro universitet,Hälsoakademin
(author)
Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules
- Article/chapterEnglish1995
Publisher, publication year, extent ...
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Elsevier BV,1995
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-20222
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-20222URI
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https://doi.org/10.1016/0960-0760(94)00155-fDOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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The cellular distribution of the glucocorticoid receptor (GR) has not yet been firmly established. The extensive literature indicates that GR is present both in the cytoplasm and the cell nucleus, however, some studies have failed to detect cytoplasmic GR. It is still controversial as to whether GR is randomly diffusing in the cytoplasm and nucleus, or if the GR-distribution is organized or controlled in some way, which may be of importance for the transduction of glucocorticoid effects to cells. There is evidence that both non-activated and activated GR is associated with the plasma membrane, a number of cytoplasmic organelles and the nucleus. Both morphological and biochemical evidence show that GR is associated with microtubules during different stages of the cell cycle, i.e. GR co-localizes, co-purifies and co-polymerizes with tubulin. This indicates that GR is structurally linked to the intracellular MT-network which may be of importance in the mechanism of action of glucocorticoid hormones. The literature in this field is reviewed including the reported data on subcellular GR-localization.
Subject headings and genre
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Cellforskning
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Cell Research
Added entries (persons, corporate bodies, meetings, titles ...)
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Wikström, A. C.
(author)
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Gustafsson, J. A.
(author)
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Örebro universitetHälsoakademin
(creator_code:org_t)
Related titles
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In:Journal of Steroid Biochemistry and Molecular Biology: Elsevier BV52:1, s. 1-160960-07601879-1220
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