Estrogen receptor β in NSCLC: prevalence, proliferative influence, prognostic impact and smoking

Estrogen receptor β in NSCLC : prevalence, proliferative influence, prognostic impact and smoking

In non-small cell lung carcinoma (NSCLC) there are gender differences. The female gender is associated with more adenocarcinomas (ADCA), among both smokers and non-smokers compared to men. Women with NSCLC have a better prognosis compared to men, regardless of other factors. A possible role for estrogen receptor (ER) signalling has been proposed and experimental as well as epidemiological data supports this view. In a material of NSCLC (n=262), ERβ and cyclins A and A2 were studied by immunohistochemistry on formalin-fixed paraffin embedded tissue. In 137 of those cases, frozen material was available, on which expression analysis of ESR2 (ERβ) and cyclin A1 were performed. Data was correlated to histology, gender, smoking habits, stage and clinical outcome.ERβ was expressed in 86% of the cases. ERβ was most frequently expressed in Stage I ADCAs, especially in male subjects. A correlation between ERβ expression and cyclins was observed in ADCA, also with a male predominance. ERβ transcripts had a positive prognostic impact in ADCA. ERβ transcripts were also increased in NSCLC among smokers compared to non-smokers.In conclusion, we report data supporting a role for ERβ in lung ADCAs where ERβ could be a biomarker for future targeted therapies.

Helenius, GiselaDept of Laboratory Medicine Örebro University Hospital, SE70185 Örebro, Sweden (författare)
Fernandes, OswaldoDept of Thoracic Surgery Örebro University Hospital, SE70185 Örebro, Sweden (författare)
Karlsson, Mats G.School of Health and Medical Sciences, Örebro University, SE70182 Örebro, Sweden, and Dept of Laboratory Medicine, Örebro University Hospital, SE70185 Örebro, Sweden (författare)
Örebro universitetHälsoakademin (creator_code:org_t)

Av författaren/redakt...: Karlsson, Christ ...; Helenius, Gisela; Fernandes, Oswal ...; Karlsson, Mats G ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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