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Sökning: (swepub) lar1:(oru) pers:(Tysk Curt) conttype:(refereed) > Infliximab or cyclo...

  • Sjöberg, Mats,1965-Department of Medicine, Skaraborgs hospital, Lidköping, Sweden (författare)

Infliximab or cyclosporine as rescue therapy in hospitalized patients with steroid-refractory ulcerative colitis : a retrospective observational study

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2012
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-21631
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-21631URI
  • https://doi.org/10.1002/ibd.21680DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170754URI
  • https://lup.lub.lu.se/record/2355238URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123885524URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-74846URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Cyclosporine (CsA) or infliximab (IFX) are used as rescue therapies in steroid-refractory, severe attacks of ulcerative colitis (UC). There are no data comparing the efficacy of these two alternatives. Methods: Outcome of rescue therapy was retrospectively studied in two cohorts of patients hospitalized due to steroid-refractory moderate to severe UC: 1) a Swedish-Danish cohort (n 49) treated with a single infusion of IFX; 2) an Austrian cohort (n 43) treated with intravenous CsA. After successful rescue therapy, maintenance immunomodulator treatment was given to 27/33 (82%) of IFX patients and to 31/40 (78%) of CsA patients. Endpoints were colectomy-free survival at 3 and 12 months. Kaplan-Meier and Cox regression models were used to evaluate the association between treatment groups and colectomy. Results: At 15 days, colectomy-free survival in the IFX cohort was 36/49 (73%) versus 41/43 (95%) in the CsA cohort (P = 0.005), at 3 months 33/49 (67%) versus 40/43 (93%) (P = 0.002), and at 12 months 28/49 (57%) versus 33/43 (77%) (P = 0.034). After adjusting for potential confounding factors, Cox regression analysis yielded adjusted hazard ratios for risk of colectomy in IFX-treated patients of 11.2 (95% confidence interval [CI] 2.4-53.1, P = 0.002) at 3 months and of 3.0 (95% CI 1.1-8.2, P = 0.030) at 12 months in comparison with CsA-treated patients. There were no opportunistic infections or mortality. Conclusions: Colectomy frequencies were significantly lower after rescue therapy with CsA than with a single infusion of IFX both at 3 and 12 months' follow-up. The superiority of CsA was seen principally during the first 15 days.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Walch, AndreaDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria (författare)
  • Hellström, Per M.,1954-Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria,Karolinska University Hospital, Solna(Swepub:uu)perhe742 (författare)
  • Gustavsson, Anders,1964-Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)argn (författare)
  • Järnerot, GunnarÖrebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden (författare)
  • Vogelsang, HaraldDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria (författare)
  • Hertervig, ErikLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Lund University(Swepub:lu)med-ehe (författare)
  • Novacek, GottfriedDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria (författare)
  • Friis-Liby, IngalillDepartment of Medicine, Division of Gastroenterology, Sahlgrenska University Hospital, Gothenburg, Sweden (författare)
  • Blomquist, LarsDepartment of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Stockholm, Sweden (författare)
  • Angelberger, SieglindeDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria (författare)
  • Karlén, PerKarolinska Institutet,Södersjukhuset, Stockholm (författare)
  • Granno, ChristerDepartment of Medicine, Division of Gastroenterology, Ryhov Hospital, Jönköping, Sweden (författare)
  • Vilien, MogensDivision of Gastroenterology, Hilleroed Hospital, Hilleroed, Denmark (författare)
  • Ström, MagnusÖstergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)magst47 (författare)
  • Verbaan, HansLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital, Malmö(Swepub:lu)medf-hve (författare)
  • Hellström, Per M.Department of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Stockholm, Sweden (författare)
  • Dejaco, ClemensDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria (författare)
  • Magnuson, AndersClinical epidemiology and biostatistic unit, Örebro University Hospital, Örebro, Sweden (författare)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jshn (författare)
  • Reinisch, WalterDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria (författare)
  • Tysk, Curt,1949-Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University Hospital(Swepub:oru)ctk (författare)
  • Department of Medicine, Skaraborgs hospital, Lidköping, SwedenDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Inflammatory Bowel Diseases: John Wiley & Sons18:2, s. 212-2181078-09981536-4844

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