Risk of prostate cancer in a population-based cohort of men with coeliac disease

Background: Prostate cancer (PC) is a leading cause of fatal cancer in men in developed countries. Coeliac disease (CD) has previously been linked to a raised cancer risk, and changes in some exposures following a CD diagnosis might hypothetically raise PC risk.Methods: We identified 10 995 patients with CD who had undergone a small intestinal biopsy in 1969-2007. Statistics Sweden then identified 54 233 age-matched male reference individuals from the general population. PC data were obtained from the Swedish Cancer Register. Hazard ratios (HRs) for PC were estimated using Cox regression analysis.Results: During follow-up, 185 individuals with CD (expected = 200) had an incident diagnosis of PC. This corresponds to a HR of 0.92 (0.79-1.08) (with 95% confidence interval) and an absolute risk reduction of 15/100 000 person-years among those with CD. An increased risk was not observed even when identification of PC began 5 years after biopsy.Conclusion: Our conclusion is that a CD diagnosis does not represent an increased risk for PC.

Fall, Katja,1971-Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Epidemiology, Harvard School of Public Health, Boston, US,Clinical Epidemiology and Biostatistics(Swepub:oru)kafl (författare)
Montgomery, Scott M.,1961-Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Primary Care and Public Health, Charing Cross Hospital, Imperial College, London, UK,Clinical Epidemiology and Biostatistics(Swepub:oru)smy (författare)
Karolinska InstitutetInstitutionen för hälsovetenskap och medicin (creator_code:org_t)

Ingår i:British Journal of CancerLondon, United Kingdom : Nature Publishing Group106:1, s. 217-2210007-09201532-1827

Av författaren/redakt...: Ludvigsson, Jona ...; Fall, Katja, 197 ...; Montgomery, Scot ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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