L773:0165 2478 OR L773:1879 0542
Sökning: L773:0165 2478 OR L773:1879 0542 > (2010-2014) > C1q regulates colla...
- Skoglund, CarolineLinköpings universitet,Farmakologi,Hälsouniversitetet,Molekylär ytfysik och nanovetenskap (författare)
C1q regulates collagen-dependent production of reactive oxygen species, aggregation and levels of soluble P-selectin in whole blood
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
- Amsterdam, Netherlands :Elsevier,2012
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-22496
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-22496URI
- https://doi.org/10.1016/j.imlet.2011.11.003DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76534URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Funding Agencies:strategic research area "Materials in Medicine" County Council of Östergötland Swedish Research Council Swedish Society of Medicine Swedish Fund for Research Without Animal Experiments Eleanora Demoroutis Nanna Svartz foundation Magn. Bergvall foundation Lars Hiertas foundation Goljes research foundation
- Funding Agencies|strategic research area "Materials in Medicine"||County Council of Ostergotland||Swedish Research Council||Heart and Lung Foundation||Swedish Society of Medicine||Swedish Fund for Research Without Animal Experiments||Eleanora Demoroutis||Nanna Svartz foundation||Magn. Bergvall foundation||Lars Hiertas foundation||Goljes research foundation||
- Blood platelets express several receptors involved in immunity (e.g. complement-, toll-like- and Fc gamma-receptors) and release inflammatory mediators. Furthermore, formation of platelet-leukocyte aggregates has an important role during inflammatory conditions such as coronary artery disease. Thus, apart from their well-known role in haemostasis, platelets are today also recognized as cells with immunomodulatory properties. We have previously reported regulatory effects of complement protein 1q (C1q) on platelet activation in experimental setups using isolated cells. In the present study we have proceeded by investigating effects of C1q on collagen-induced aggregation, production of reactive oxygen species (ROS), formation of platelet-leukocyte aggregates and levels of soluble P-selectin in whole blood. Impedance measurements showed that C1q inhibited collagen-induced aggregation whereas it potentiated the collagen-provoked production of ROS in a luminol-dependent chemiluminescence assay. The effects of C1q on aggregation and ROS-production were dependent upon platelets, as they were no longer observed in presence of the platelet (GpIIb/IIIa) inhibitor Reopro. Furthermore, the levels of soluble P-selectin were found to be lowered upon treatment with C1q prior to addition of collagen. There was also a trend towards a decreased formation of large platelet-leukocyte aggregates in collagen-stimulated whole blood following C1q treatment. In conclusion, our data indicate that C1q could have a role in regulating platelet activation and associated leukocyte recruitment during vessel wall injury. This has implications for inflammatory disorders such as coronary artery disease.
Ämnesord och genrebeteckningar
- NATURVETENSKAP Biologi Immunologi hsv//swe
- NATURAL SCIENCES Biological Sciences Immunology hsv//eng
- C1q
- collagen
- platelet
- platelet–leukocyte aggregate
- reactive oxygen species
- whole blood
- Medicine
- Medicin
- MEDICINE
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Wetterö, JonasLinköpings universitet,Reumatologi,Hälsouniversitetet(Swepub:liu)jonwe26 (författare)
- Bengtsson, Torbjörn,1955-Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Biomedicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden(Swepub:oru)tbn (författare)
- Linköpings universitetFarmakologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Immunology LettersAmsterdam, Netherlands : Elsevier142:1-2, s. 28-330165-24781879-0542
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