Search: (swepub) lar1:(oru) pers:(Tysk Curt) conttype:(refereed) >
Resequencing of pos...
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
-
- Momozawa, Yukihide (author)
- Fac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R
-
- Mni, Myriam (author)
- Fac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R
-
- Nakamura, Kayo (author)
- Fac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R
-
show more...
-
- Coppieters, Wouter (author)
- Fac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R
-
- Almer, Sven (author)
- Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
-
- Amininejad, Leila (author)
- Dept Gastroenterol, Erasme Hosp, Univ Libre Brussels, Brussels, Belgium,University Libre Bruxelles
-
- Cleynen, Isabelle (author)
- Dept Pathophysiol, Gastroenterol Sect, Catholic Univ Louvain, Louvain, Belgium,Catholic University Louvain
-
- Colombel, Jean-Frédéric (author)
- Registre MICI Nord Quest France EPIMAD, Hop Calmette, Lille, France
-
- de Rijk, Peter (author)
- Dept Mol Genet, Univ Antwerp VIB, Antwerp, Belgium,University Antwerp VIB
-
- Dewit, Olivier (author)
- Dept Gastroenterol, Clin Univ St Luc, Catholic Univ Louvain, Brussels, Belgium,Catholic University Louvain
-
- Finkel, Yigael (author)
- Karolinska Institutet,Karolinska Childrens Hospital
-
- Gassull, Miquel A. (author)
- Dept Gastroenterol, Hosp Badalona Germans Trias & Pujol, Badalona, Spain,Hospital Badalona Germans Trias and Pujol
-
- Goossens, Dirk (author)
- Dept Mol Genet, Univ Antwerp VIB, Antwerp, Belgium,University Antwerp VIB
-
- Laukens, Debby (author)
- Dept Gastroenterol, Univ Hosp, Univ Ghent, Ghent, Belgium,University Ghent
-
- Lémann, Marc (author)
- AP HP, Dept Gastroenterol, Hop St Louis, Univ Paris 07, Paris, France,University Paris 07
-
- Libioulle, Cécile (author)
- Fac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R
-
- O'Morain, Colm (author)
- Adelaide & Meath Hosp, Dublin, Ireland,Adelaide and Meath Hospital
-
- Reenaers, Catherine (author)
- Fac Med, Univ Liege B34, Liege, Belgium,GIGA R
-
- Rutgeerts, Paul (author)
- Dept Pathophysiol, Gastroenterol Sect, Catholic Univ Louvain, Louvain, Belgium,Catholic University Louvain
-
- Tysk, Curt (author)
- Örebro universitet,Hälsoakademin,Orebro Med Centre Hospital
-
- Zelenika, Diana (author)
- Ctr Natl Genotypage, Evry, France,Centre Natl Genotypage, Evry
-
- Lathrop, Mark (author)
- Ctr Natl Genotypage, Evry, France,Centre Natl Genotypage, Evry, France
-
- Del-Favero, Jurgen (author)
- Dept Mol Genet, Univ Antwerp VIB, Antwerp, Belgium,University Antwerp VIB
-
- Hugot, Jean-Pierre (author)
- INSERM, U843, Hop Robert Debre, IParis, France
-
- de Vos, Martine (author)
- Dept Gastroenterol,Univ Hosp, Univ Ghent, Ghent, Belgium,University Ghent
-
- Franchimont, Denis (author)
- Dept Gastroenterol, Erasme Hosp, Univ Libre Brussels, Brussels, Belgium,University Libre Bruxelles
-
- Vermeire, Severine (author)
- Dept Pathophysiol, Gastroenterol Sect, Catholic Univ Louvain, Louvain, Belgium,Catholic University Louvain
-
- Louis, Edouard (author)
- Fac Med, Univ Liege B34, Liege, Belgium,GIGA R
-
- Georges, Michel (author)
- Fac Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R
-
show less...
-
(creator_code:org_t)
- 2010-12-12
- 2011
- English.
-
In: Nature Genetics. - New York : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 43:1, s. 43-47
- Related links:
-
https://biblio.ugent...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Genome-wide association studies (GWAS) have identified dozens of risk loci for many complex disorders, including Crohn's disease. However, common disease-associated SNPs explain at most ∼20% of the genetic variance for Crohn's disease. Several factors may account for this unexplained heritability, including rare risk variants not adequately tagged thus far in GWAS. That rare susceptibility variants indeed contribute to variation in multifactorial phenotypes has been demonstrated for colorectal cancer, plasma high-density lipoprotein cholesterol levels, blood pressure, type 1 diabetes, hypertriglyceridemia and, in the case of Crohn's disease, for NOD2 (refs. 14,15). Here we describe the use of high-throughput resequencing of DNA pools to search for rare coding variants influencing susceptibility to Crohn's disease in 63 GWAS-identified positional candidate genes. We identify low frequency coding variants conferring protection against inflammatory bowel disease in IL23R, but we conclude that rare coding variants in positional candidates do not make a large contribution to inherited predisposition to Crohn's disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Genetik
- Genetics
- Medicine
- Medicin
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Momozawa, Yukihi ...
-
Mni, Myriam
-
Nakamura, Kayo
-
Coppieters, Wout ...
-
Almer, Sven
-
Amininejad, Leil ...
-
show more...
-
Cleynen, Isabell ...
-
Colombel, Jean-F ...
-
de Rijk, Peter
-
Dewit, Olivier
-
Finkel, Yigael
-
Gassull, Miquel ...
-
Goossens, Dirk
-
Laukens, Debby
-
Lémann, Marc
-
Libioulle, Cécil ...
-
O'Morain, Colm
-
Reenaers, Cather ...
-
Rutgeerts, Paul
-
Tysk, Curt
-
Zelenika, Diana
-
Lathrop, Mark
-
Del-Favero, Jurg ...
-
Hugot, Jean-Pier ...
-
de Vos, Martine
-
Franchimont, Den ...
-
Vermeire, Severi ...
-
Louis, Edouard
-
Georges, Michel
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Nature Genetics
- By the university
-
Örebro University
-
Karolinska Institutet
-
Linköping University