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Search: (swepub) lar1:(oru) pers:(Tysk Curt) conttype:(refereed) > Resequencing of pos...

  • Momozawa, YukihideFac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R (author)

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2010-12-12
  • New York :Nature Publishing Group,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-24209
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-24209URI
  • https://doi.org/10.1038/ng.733DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121810674URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-64757URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Genome-wide association studies (GWAS) have identified dozens of risk loci for many complex disorders, including Crohn's disease. However, common disease-associated SNPs explain at most ∼20% of the genetic variance for Crohn's disease. Several factors may account for this unexplained heritability, including rare risk variants not adequately tagged thus far in GWAS. That rare susceptibility variants indeed contribute to variation in multifactorial phenotypes has been demonstrated for colorectal cancer, plasma high-density lipoprotein cholesterol levels, blood pressure, type 1 diabetes, hypertriglyceridemia and, in the case of Crohn's disease, for NOD2 (refs. 14,15). Here we describe the use of high-throughput resequencing of DNA pools to search for rare coding variants influencing susceptibility to Crohn's disease in 63 GWAS-identified positional candidate genes. We identify low frequency coding variants conferring protection against inflammatory bowel disease in IL23R, but we conclude that rare coding variants in positional candidates do not make a large contribution to inherited predisposition to Crohn's disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mni, MyriamFac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R (author)
  • Nakamura, KayoFac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R (author)
  • Coppieters, WouterFac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R (author)
  • Almer, SvenÖstergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)sveal38 (author)
  • Amininejad, LeilaDept Gastroenterol, Erasme Hosp, Univ Libre Brussels, Brussels, Belgium,University Libre Bruxelles (author)
  • Cleynen, IsabelleDept Pathophysiol, Gastroenterol Sect, Catholic Univ Louvain, Louvain, Belgium,Catholic University Louvain (author)
  • Colombel, Jean-FrédéricRegistre MICI Nord Quest France EPIMAD, Hop Calmette, Lille, France (author)
  • de Rijk, PeterDept Mol Genet, Univ Antwerp VIB, Antwerp, Belgium,University Antwerp VIB (author)
  • Dewit, OlivierDept Gastroenterol, Clin Univ St Luc, Catholic Univ Louvain, Brussels, Belgium,Catholic University Louvain (author)
  • Finkel, YigaelKarolinska Institutet,Karolinska Childrens Hospital (author)
  • Gassull, Miquel A.Dept Gastroenterol, Hosp Badalona Germans Trias & Pujol, Badalona, Spain,Hospital Badalona Germans Trias and Pujol (author)
  • Goossens, DirkDept Mol Genet, Univ Antwerp VIB, Antwerp, Belgium,University Antwerp VIB (author)
  • Laukens, DebbyDept Gastroenterol, Univ Hosp, Univ Ghent, Ghent, Belgium,University Ghent (author)
  • Lémann, MarcAP HP, Dept Gastroenterol, Hop St Louis, Univ Paris 07, Paris, France,University Paris 07 (author)
  • Libioulle, CécileFac Vet Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R (author)
  • O'Morain, ColmAdelaide & Meath Hosp, Dublin, Ireland,Adelaide and Meath Hospital (author)
  • Reenaers, CatherineFac Med, Univ Liege B34, Liege, Belgium,GIGA R (author)
  • Rutgeerts, PaulDept Pathophysiol, Gastroenterol Sect, Catholic Univ Louvain, Louvain, Belgium,Catholic University Louvain (author)
  • Tysk, CurtÖrebro universitet,Hälsoakademin,Orebro Med Centre Hospital(Swepub:oru)ctk (author)
  • Zelenika, DianaCtr Natl Genotypage, Evry, France,Centre Natl Genotypage, Evry (author)
  • Lathrop, MarkCtr Natl Genotypage, Evry, France,Centre Natl Genotypage, Evry, France (author)
  • Del-Favero, JurgenDept Mol Genet, Univ Antwerp VIB, Antwerp, Belgium,University Antwerp VIB (author)
  • Hugot, Jean-PierreINSERM, U843, Hop Robert Debre, IParis, France (author)
  • de Vos, MartineDept Gastroenterol,Univ Hosp, Univ Ghent, Ghent, Belgium,University Ghent (author)
  • Franchimont, DenisDept Gastroenterol, Erasme Hosp, Univ Libre Brussels, Brussels, Belgium,University Libre Bruxelles (author)
  • Vermeire, SeverineDept Pathophysiol, Gastroenterol Sect, Catholic Univ Louvain, Louvain, Belgium,Catholic University Louvain (author)
  • Louis, EdouardFac Med, Univ Liege B34, Liege, Belgium,GIGA R (author)
  • Georges, MichelFac Med, Univ Liege B34, Liege, Belgium,Grp Interdisciplinaire Genoprote Appliquee GIGA R (author)
  • Fac Vet Med, Univ Liege B34, Liege, BelgiumGrp Interdisciplinaire Genoprote Appliquee GIGA R (creator_code:org_t)

Related titles

  • In:Nature GeneticsNew York : Nature Publishing Group43:1, s. 43-471061-40361546-1718

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