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Suicide and cardiov...
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Fang, FangKarolinska Institutet
(författare)
Suicide and cardiovascular death after a cancer diagnosis
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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Walton, USA :Massachusetts Medical Society,2012
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-24620
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-24620URI
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https://doi.org/10.1056/NEJMoa1110307DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124312917URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background: Receiving a diagnosis of cancer is a traumatic experience that may trigger immediate adverse health consequences beyond the effects of the disease or treatment.Methods: Using Poisson and negative binomial regression models, we conducted a historical cohort study involving 6,073,240 Swedes to examine the associations between a cancer diagnosis and the immediate risk of suicide or death from cardiovascular causes from 1991 through 2006. To adjust for unmeasured confounders, we also performed a nested, self-matched case-crossover analysis among all patients with cancer who died from suicide or cardiovascular diseases in the cohort.Results: As compared with cancer-free persons, the relative risk of suicide among patients receiving a cancer diagnosis was 12.6 (95% confidence interval [CI], 8.6 to 17.8) during the first week (29 patients; incidence rate, 2.50 per 1000 person-years) and 3.1 (95% CI, 2.7 to 3.5) during the first year (260 patients; incidence rate, 0.60 per 1000 person-years). The relative risk of cardiovascular death after diagnosis was 5.6 (95% CI, 5.2 to 5.9) during the first week (1318 patients; incidence rate, 116.80 per 1000 person-years) and 3.3 (95% CI, 3.1 to 3.4) during the first 4 weeks (2641 patients; incidence rate, 65.81 per 1000 person-years). The risk elevations decreased rapidly during the first year after diagnosis. Increased risk was particularly prominent for cancers with a poor prognosis. The case-crossover analysis largely confirmed results from the main analysis.Conclusions: In this large cohort study, patients who had recently received a cancer diagnosis had increased risks of both suicide and death from cardiovascular causes, as compared with cancer-free persons. (Funded by the Swedish Council for Working Life and Social Research and others.).
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fall, Katja,1971-Örebro universitet,Institutionen för hälsovetenskap och medicin,Clinical Epidemiology and Biostatistics Unit, Örebro University Hospital, Örebro, Sweden; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland(Swepub:oru)kafl
(författare)
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Mittleman, M.A.Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
(författare)
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Sparen, P.Karolinska Institutet
(författare)
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Ye, W.M.Karolinska Institutet
(författare)
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Adami, H. O.Karolinska Institutet
(författare)
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Valdimarsdottir, UnnurKarolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för hälsovetenskap och medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:New England Journal of MedicineWalton, USA : Massachusetts Medical Society366:14, s. 1310-13180028-47931533-4406
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