Clustering of polyclonal VanB-type vancomycin-resistant Enterococcus faecium in a low-endemic area was associated with CC17-genogroup strains harbouring transferable vanB2-Tn5382 and pRUM-like repA containing plasmids with axe-txe plasmid addiction systems

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Bjørkeng, EvaResearch Group for Host-Microbe Interactions, Department of Medical Biology, University of Tromsø, Tromsø, Norway (författare)

Clustering of polyclonal VanB-type vancomycin-resistant Enterococcus faecium in a low-endemic area was associated with CC17-genogroup strains harbouring transferable vanB2-Tn5382 and pRUM-like repA containing plasmids with axe-txe plasmid addiction systems

Artikel/kapitelEngelska2011

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2011-02-25
Wiley-Blackwell,2011
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LIBRIS-ID:oai:DiVA.org:oru-25341
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-25341URI
https://doi.org/10.1111/j.1600-0463.2011.02724.xDOI

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Funding Agencies:Research Committee of Örebro County Council, Sweden Norwegian Research Council 165997 183653/S10 Northern Norway Regional Health Authority European Commission LSHE-CT-2007-03410 'ACE'
VanB-type vancomycin-resistant Enterococcus faecium isolates (n = 17) from 15 patients at the Örebro University hospital in Sweden during a span of 18 months was characterized. All patients had underlying disorders and received broad-spectrum antimicrobial therapy. Pulsed-field gel electrophoresis (PFGE) grouped 14 isolates in three PFGE types and three isolates in unique PFGE patterns. All isolates had multi-locus sequence types [ST17 (n = 5); ST18 (n = 3); ST125 (n = 7); ST262 (n = 1); ST460 (n = 1)] belonging to the successful hospital-adapted clonal complex 17 (CC17), harboured CC17-associated virulence genes, were vanB2-positive and expressed diverse vancomycin minimum inhibitory concentration (MICs; 8 to > 256 mg/L). Isolate 1 had a unique PFGE type and a chromosomal transferable vanB2-Tn5382 element. Interestingly, the other five PFGE types had Tn5382 located on plasmids containing pRUM-like repA and a plasmid addiction system (axe-txe) shown by co-hybridization analysis of PFGE-separated S1-nuclease digested total DNA. The resistance plasmids were mainly of 120-kb and supported intraspecies vanB transfer. Two strains were isolated from patient 6 and we observed a possible transfer of the vanB2-resistance genes from PFGE type III ST460 to a more successful PFGE type I ST125. This latter PFGE type I ST125 became the predominant type afterwards. Our observations support the notion that vanB-type vancomycin-resistant Enterococcus faecium can persist in a low-endemic area through successful clones and plasmids with stability functions in hospital patients with known risk factors.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
E; faecium; VRE; axetxe; CC17

Biuppslag (personer, institutioner, konferenser, titlar ...)

Rasmussen, Gunlög,1973-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)grn (författare)
Sundsfjord, ArnfinnResearch Group for Host-Microbe Interactions, Department of Medical Biology, University of Tromsø, Tromsø, Norway; Department of Microbiology and Infection Control, Reference Centre for Detection of Antimicrobial Resistance, University Hospital of North-Norway, Tromsø, Norway (författare)
Sjöberg, LennartDepartment of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden (författare)
Hegstad, KristinResearch Group for Host-Microbe Interactions, Department of Medical Biology, University of Tromsø, Tromsø, Norway; Department of Microbiology and Infection Control, Reference Centre for Detection of Antimicrobial Resistance, University Hospital of North-Norway, Tromsø, Norway (författare)
Söderquist, Bo,1955-Örebro universitet,Hälsoakademin,Department of Infectious Diseases and Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)bost (författare)
Research Group for Host-Microbe Interactions, Department of Medical Biology, University of Tromsø, Tromsø, NorwayInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

Ingår i:Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS): Wiley-Blackwell119:4-5, s. 247-2580903-46411600-0463

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