Cystic fibrosis gene mutations and gastrointestinal diseases

Background: This study examined if CF mutation heterozygosity is associated with diseases of gastrointestinal epithelial barrier function. Design and methods: Swedish registers identified 865 patients with a diagnosis of CF between 1968 and 2003 and matched with 8101 individuals without CF. Gastrointestinal disease risk was examined among 1534 biological parents and 1396 siblings of CF patients, compared with 15,526 parents and 15,542 siblings of individuals without CF. Results: First-degree relatives of CF patients were not at lower risk of the gastrointestinal diseases, in contrast with a raised risk among CF patients. Conclusion: Heterozygosity for CF gene mutations does not protect against gastrointestinal diseases where impaired barrier function may be relevant. (C) 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Ekbom, AndersKarolinska Institutet (författare)
Askling, JohanKarolinska Institutet (författare)
Johannesson, MarieDepartment, Paediatrics and Child Health, University of Otago, Wellington, New Zealand(Swepub:oru)mijn (författare)
Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Primary Care and Social Medicine, Charing Cross Hospital, Imperial College, London, United Kingdom,Clinical Epidemiology and Biostatistics(Swepub:oru)smy (författare)
Karolinska InstitutetDepartment, Paediatrics and Child Health, University of Otago, Wellington, New Zealand (creator_code:org_t)

Ingår i:Journal of Cystic Fibrosis: Elsevier BV9:4, s. 288-2911569-19931873-5010

Av författaren/redakt...: Bahmanyar, Shahr ...; Ekbom, Anders; Askling, Johan; Johannesson, Mar ...; Montgomery, Scot ...

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