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Hepatocyte growth f...
Hepatocyte growth factor in patients with coronary artery disease and its relation to periodontal condition
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- Lönn, Johanna, 1982- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,PEAS Institute, Linköping, Sweden,Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Starkhammar Johansson, Carin (author)
- Linköpings universitet,Kardiologi,Hälsouniversitetet
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- Kälvegren, Hanna (author)
- Linköpings universitet,Kardiologi,Hälsouniversitetet
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- Brudin, Lars (author)
- Linköpings universitet,Klinisk fysiologi,Hälsouniversitetet
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- Skoglund, Caroline (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska högskolan
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- Garvin, Peter (author)
- Linköpings universitet,Socialmedicin och folkhälsovetenskap,Hälsouniversitetet
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- Särndahl, Eva, 1963- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department ofCardiology, Örebro UniversityHospital, Örebro, Sweden,Department of Cardiology, Örebro University Hospital, Örebro, Sweden
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- Ravald, Nils (author)
- Linköpings universitet,Kardiologi,Hälsouniversitetet
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- Richter, Arina (author)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken US
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- Bengtsson, Torbjörn, 1955- (author)
- Örebro universitet,Institutionen för läkarutbildning,Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Nayeri, Fariba (author)
- Östergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland,PEAS Institute
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Results in Immunology. - : Elsevier BV. - 2211-2839. ; 2, s. 7-12
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Hepatocyte growth factor (HGF) is an angiogenic, cardioprotective factor important for tissue and vascular repair. High levels of HGF are associated with chronic inflammatory diseases, such as coronary artery disease (CAD) and periodontitis, and are suggested as a marker of the ongoing atherosclerotic event in patients with CAD. Periodontal disease is more prevalent among patients with CAD than among healthy people. Recent studies indicate a reduced biological activity of HGF in different chronic inflammatory conditions. Biologically active HGF has high affinity to heparan sulfate proteoglycan (HSPG) on cell-membrane and extracellular matrix. The aim of the study was to investigate the serum concentration and the biological activity of HGF with ELISA and surface plasmon resonance (SPR), respectively, before and at various time points after percutaneous coronary intervention (PCI) in patients with CAD, and to examine the relationship with periodontal condition. The periodontal status of the CAD patients was examined, and the presence of P. gingivalis in periodontal pockets was analyzed with PCR. The HGF concentration was significantly higher, at all time-points, in patients with CAD compared to the age-matched controls (P< 0.001), but was independent of periodontal status. The HGF concentration and the affinity to HSPG adversely fluctuated over time, and the biological activity increased one month after intervention in patients without periodontitis. We conclude that elevated concentration of HGF but with reduced biological activity might indicate a chronic inflammatory profile in patients with CAD and periodontitis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Hepatocyte growth factor
- coronary artery disease
- angiography
- periodontal disease
- porphyromonas gingivalis
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lönn, Johanna, 1 ...
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Starkhammar Joha ...
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Kälvegren, Hanna
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Brudin, Lars
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Skoglund, Caroli ...
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Garvin, Peter
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Särndahl, Eva, 1 ...
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Ravald, Nils
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Richter, Arina
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Bengtsson, Torbj ...
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Nayeri, Fariba
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Results in Immun ...
- By the university
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Örebro University
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Linköping University