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Genome-wide associa...
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
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McGovern, Dermot P B (author)
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Gardet, Agnès (author)
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- Törkvist, Leif (author)
- Karolinska Institutet
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Goyette, Philippe (author)
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Essers, Jonah (author)
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Taylor, Kent D (author)
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Neale, Benjamin M (author)
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Ong, Rick T H (author)
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Lagacé, Caroline (author)
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Li, Chun (author)
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Green, Todd (author)
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Stevens, Christine R (author)
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Beauchamp, Claudine (author)
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Fleshner, Phillip R (author)
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- Carlson, Marie (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- D'Amato, Mauro (author)
- Karolinska Institutet
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Hälsoakademin
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- Hibberd, Martin L (author)
- Karolinska Institutet
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Lördal, Mikael (author)
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- Padyukov, Leonid (author)
- Karolinska Institutet
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Andriulli, Angelo (author)
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Colombo, Elisabetta (author)
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Latiano, Anna (author)
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Palmieri, Orazio (author)
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Bernard, Edmond-Jean (author)
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Deslandres, Colette (author)
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Hommes, Daan W (author)
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de Jong, Dirk J (author)
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Stokkers, Pieter C (author)
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Weersma, Rinse K (author)
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Sharma, Yashoda (author)
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Silverberg, Mark S (author)
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Cho, Judy H (author)
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Wu, Jing (author)
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Roeder, Kathryn (author)
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Brant, Steven R (author)
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Schumm, L Phillip (author)
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Duerr, Richard H (author)
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Dubinsky, Marla C (author)
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Glazer, Nicole L (author)
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Haritunians, Talin (author)
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Ippoliti, Andy (author)
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Melmed, Gil Y (author)
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Siscovick, David S (author)
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Vasiliauskas, Eric A (author)
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Targan, Stephan R (author)
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Annese, Vito (author)
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Wijmenga, Cisca (author)
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- Pettersson, Sven (author)
- Karolinska Institutet
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Rotter, Jerome I (author)
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Xavier, Ramnik J (author)
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Daly, Mark J (author)
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Rioux, John D (author)
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Seielstad, Mark (author)
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(creator_code:org_t)
- 2010-03-14
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:4, s. 332-337
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation underlying ulcerative colitis risk, we present two distinct genome-wide association studies of ulcerative colitis and their joint analysis with a previously published scan, comprising, in aggregate, 2,693 individuals with ulcerative colitis and 6,791 control subjects. Fifty-nine SNPs from 14 independent loci attained an association significance of P < 10(-5). Seven of these loci exceeded genome-wide significance (P < 5 x 10(-8)). After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3). We confirmed association with 14 previously identified ulcerative colitis susceptibility loci, and an analysis of acknowledged Crohn's disease loci showed that roughly half of the known Crohn's disease associations are shared with ulcerative colitis. These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Medicine
- Medicin
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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McGovern, Dermot ...
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Gardet, Agnès
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Törkvist, Leif
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Goyette, Philipp ...
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Essers, Jonah
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Taylor, Kent D
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show more...
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Neale, Benjamin ...
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Ong, Rick T H
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Lagacé, Caroline
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Li, Chun
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Green, Todd
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Stevens, Christi ...
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Beauchamp, Claud ...
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Fleshner, Philli ...
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Carlson, Marie
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D'Amato, Mauro
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Halfvarson, Jona ...
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Hibberd, Martin ...
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Lördal, Mikael
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Padyukov, Leonid
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Andriulli, Angel ...
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Colombo, Elisabe ...
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Latiano, Anna
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Palmieri, Orazio
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Bernard, Edmond- ...
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Deslandres, Cole ...
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Hommes, Daan W
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de Jong, Dirk J
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Stokkers, Pieter ...
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Weersma, Rinse K
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Sharma, Yashoda
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Silverberg, Mark ...
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Cho, Judy H
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Wu, Jing
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Roeder, Kathryn
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Brant, Steven R
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Schumm, L Philli ...
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Duerr, Richard H
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Dubinsky, Marla ...
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Glazer, Nicole L
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Haritunians, Tal ...
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Ippoliti, Andy
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Melmed, Gil Y
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Siscovick, David ...
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Vasiliauskas, Er ...
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Targan, Stephan ...
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Annese, Vito
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Wijmenga, Cisca
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Pettersson, Sven
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Rotter, Jerome I
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Xavier, Ramnik J
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Daly, Mark J
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Rioux, John D
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Seielstad, Mark
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Nature Genetics
- By the university
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Örebro University
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Karolinska Institutet
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Uppsala University