Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

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Franke, Andre (author)

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Article/chapterEnglish2010

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2010-11-21
Springer Science and Business Media LLC,2010
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:oru-27404
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27404URI
https://doi.org/10.1038/ng.717DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:121622686URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
Medicine
Medicin

Added entries (persons, corporate bodies, meetings, titles ...)

McGovern, Dermot P B (author)
Barrett, Jeffrey C (author)
Wang, Kai (author)
Radford-Smith, Graham L (author)
Ahmad, Tariq (author)
Lees, Charlie W (author)
Balschun, Tobias (author)
Lee, James (author)
Roberts, Rebecca (author)
Anderson, Carl A (author)
Bis, Joshua C (author)
Bumpstead, Suzanne (author)
Ellinghaus, David (author)
Festen, Eleonora M (author)
Georges, Michel (author)
Green, Todd (author)
Haritunians, Talin (author)
Jostins, Luke (author)
Latiano, Anna (author)
Mathew, Christopher G (author)
Montgomery, Grant W (author)
Prescott, Natalie J (author)
Raychaudhuri, Soumya (author)
Rotter, Jerome I (author)
Schumm, Philip (author)
Sharma, Yashoda (author)
Simms, Lisa A (author)
Taylor, Kent D (author)
Whiteman, David (author)
Wijmenga, Cisca (author)
Baldassano, Robert N (author)
Barclay, Murray (author)
Bayless, Theodore M (author)
Brand, Stephan (author)
Büning, Carsten (author)
Cohen, Albert (author)
Colombel, Jean-Frederick (author)
Cottone, Mario (author)
Stronati, Laura (author)
Denson, Ted (author)
De Vos, Martine (author)
D'Inca, Renata (author)
Dubinsky, MarlaKarolinska Institutet (author)
Edwards, Cathryn (author)
Florin, Tim (author)
Franchimont, Denis (author)
Gearry, Richard (author)
Glas, Jürgen (author)
Van Gossum, Andre (author)
Guthery, Stephen L (author)
Halfvarson, Jonas,1970-Örebro universitet,Hälsoakademin(Swepub:oru)jshn (author)
Verspaget, Hein W (author)
Hugot, Jean-Pierre (author)
Karban, Amir (author)
Laukens, Debby (author)
Lawrance, Ian (author)
Lemann, Marc (author)
Levine, Arie (author)
Libioulle, Cecile (author)
Louis, Edouard (author)
Mowat, Craig (author)
Newman, William (author)
Panés, Julián (author)
Phillips, Anne (author)
Proctor, Deborah D (author)
Regueiro, Miguel (author)
Russell, Richard (author)
Rutgeerts, Paul (author)
Sanderson, Jeremy (author)
Sans, Miquel (author)
Seibold, Frank (author)
Steinhart, A Hillary (author)
Stokkers, Pieter C F (author)
Torkvist, LeifKarolinska Institutet (author)
Kullak-Ublick, Gerd (author)
Wilson, David (author)
Walters, Thomas (author)
Targan, Stephan R (author)
Brant, Steven R (author)
Rioux, John D (author)
D'Amato, Mauro (author)
Weersma, Rinse K (author)
Kugathasan, Subra (author)
Griffiths, Anne M (author)
Mansfield, John C (author)
Vermeire, Severine (author)
Duerr, Richard H (author)
Silverberg, Mark S (author)
Satsangi, Jack (author)
Schreiber, Stefan (author)
Cho, Judy H (author)
Annese, Vito (author)
Hakonarson, Hakon (author)
Daly, Mark J (author)
Parkes, Miles (author)
Karolinska InstitutetHälsoakademin (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC42:12, s. 1118-11251061-40361546-1718

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By the author/editor: Franke, Andre; McGovern, Dermot ...; Barrett, Jeffrey ...; Wang, Kai; Radford-Smith, G ...; Ahmad, Tariq; show more...; Lees, Charlie W; Balschun, Tobias; Lee, James; Roberts, Rebecca; Anderson, Carl A; Bis, Joshua C; Bumpstead, Suzan ...; Ellinghaus, Davi ...; Festen, Eleonora ...; Georges, Michel; Green, Todd; Haritunians, Tal ...; Jostins, Luke; Latiano, Anna; Mathew, Christop ...; Montgomery, Gran ...; Prescott, Natali ...; Raychaudhuri, So ...; Rotter, Jerome I; Schumm, Philip; Sharma, Yashoda; Simms, Lisa A; Taylor, Kent D; Whiteman, David; Wijmenga, Cisca; Baldassano, Robe ...; Barclay, Murray; Bayless, Theodor ...; Brand, Stephan; Büning, Carsten; Cohen, Albert; Colombel, Jean-F ...; Cottone, Mario; Stronati, Laura; Denson, Ted; De Vos, Martine; D'Inca, Renata; Dubinsky, Marla; Edwards, Cathryn; Florin, Tim; Franchimont, Den ...; Gearry, Richard; Glas, Jürgen; Van Gossum, Andr ...; Guthery, Stephen ...; Halfvarson, Jona ...; Verspaget, Hein ...; Hugot, Jean-Pier ...; Karban, Amir; Laukens, Debby; Lawrance, Ian; Lemann, Marc; Levine, Arie; Libioulle, Cecil ...; Louis, Edouard; Mowat, Craig; Newman, William; Panés, Julián; Phillips, Anne; Proctor, Deborah ...; Regueiro, Miguel; Russell, Richard; Rutgeerts, Paul; Sanderson, Jerem ...; Sans, Miquel; Seibold, Frank; Steinhart, A Hil ...; Stokkers, Pieter ...; Torkvist, Leif; Kullak-Ublick, G ...; Wilson, David; Walters, Thomas; Targan, Stephan ...; Brant, Steven R; Rioux, John D; D'Amato, Mauro; Weersma, Rinse K; Kugathasan, Subr ...; Griffiths, Anne ...; Mansfield, John ...; Vermeire, Severi ...; Duerr, Richard H; Silverberg, Mark ...; Satsangi, Jack; Schreiber, Stefa ...; Cho, Judy H; Annese, Vito; Hakonarson, Hako ...; Daly, Mark J; Parkes, Miles; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

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By the university: Örebro University; Karolinska Institutet

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