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Higher than expecte...
Higher than expected estradiol levels in aromatase inhibitor-treated, postmenopausal breast cancer patients
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- Kallak, Theodora Kunovac, 1985- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
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- Baumgart, Juliane, 1978- (författare)
- Department of Obstetrics and Gynecology, Örebro University Hospital, Örebro, Sweden
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- Stavreus-Evers, Anneli, 1955- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
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- Sundström Poromaa, Inger (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa
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- Moby, Lena (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa
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- Kask, Kristiina (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa,The School of Health and Medical Sciences, Örebro University, Sweden
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- Norjavaara, Ensio, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Gothenburg Pediatric Growth Research Center, Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Sweden
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- Kushnir, M. M. (författare)
- ARUP Institute for Clinical and Experimental Pathology, Salt Lake City UT, USA
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- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi
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- Nilsson, Kerstin, 1953- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Obstetrics and Gynecology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2012-02-11
- 2012
- Engelska.
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Ingår i: Climacteric. - London, United Kingdom : Informa Healthcare. - 1369-7137 .- 1473-0804. ; 15:5, s. 473-480
- Relaterad länk:
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http://informahealth...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: Vaginal estradiol is considered contraindicated in aromatase inhibitor (AI)-treated patients because of the risk of elevated estrogen levels. This leaves limited treatment options for patients experiencing gynecological symptoms. However, in clinical practice, no precise estimation has been performed of circulating estrogens and aromatase index in postmenopausal breast cancer patients on long-lasting AI or tamoxifen treatment.Methods: Steroid hormones were measured using liquid chromatography tandem mass spectrometry (LC-MS/MS) and extraction radioimmunoassay (RIA). Postmenopausal AI-treated patients (n =33) were compared with tamoxifen-treated patients (n =34) and controls without vaginal treatment (n =56), with vaginal estradiol (n =25), or with estriol (n =11) treatment.Results: By use of LC-MS/MS, median (range) estradiol plasma concentrations were 16.7 (2.4-162.6), 31.0 (13.4-77.1), 27.2 (7.8-115.8) and 33.3 (20.3-340.1) pmol/l in AI-treated breast cancer patients, tamoxifen-treated breast cancer patients, postmenopausal controls and postmenopausal controls on vaginal estradiol, respectively. The AI-treated group and subgroups had significantly lower estradiol and estrone concentrations than all other groups (p <0.05). There was extensive interindividual variation in estradiol concentration within the AI-treated group, measured using both LC-MS/MS (2.3-182.0 pmol/l) and extraction RIA (2.4-162.6 pmol/l). The AI-treated group had lower aromatase index compared to all other groups (p <0.05-0.001).Conclusion: Circulating estrogen levels may have been underestimated in previous longitudinal studies of AI-treated breast cancer patients. Additional studies are required to further evaluate the role of circulating estrogens in breast cancer patients suffering from gynecological symptoms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- Estrogens
- aromatase inhibitors
- tamoxifen
- postmenopausal women
- Medicine
- Medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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