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- Acosta, StefanLund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups (författare)
Current status on plasma biomarkers for acute mesenteric ischemia
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
- 2011-11-13
- Springer,2012
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-27904
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27904URI
- https://doi.org/10.1007/s11239-011-0660-zDOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79812URI
- https://lup.lub.lu.se/record/2220785URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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Anmärkningar
- Clinical diagnosis of acute mesenteric ischemia is difficult. The aim of this review is to provide current status on the search for an accurate plasma biomarker for acute mesenteric ischemia. A search using the medical subject heading terms marker and mesenteric ischemia or intestinal ischemia or superior mesenteric artery occlusion or mesenteric venous thrombosis in the Medline and Embase databases from 1980 to 2011. Studies without a control group or a control group consisted of healthy individuals (human studies), or studies on intestinal reperfusion were excluded. Twenty animal and twelve human studies were identified. In human studies, the studied series of patients had a control group that had a need of laparotomy (n = 2), suspected acute mesenteric ischemia (n = 7), acute abdomen (n = 2) or systemic inflammatory response syndrome (n = 1). D: -dimer has been found to be the most consistent highly sensitive early marker, but specificity was low. The follow-up study on α-glutathione S-transferase yielded inferior sensitivity and accuracy than the preliminary study, clearly questioning the value of this marker. Intestinal fatty acid binding globulin (I-FABP) and D: -lactate are both interesting markers, but the results were conflicting. Different cut-off levels have been used in the studies on I-FABP. The encouraging preliminary result of cobalt-albumin and urinary FABP as an accurate marker needs to be addressed in other study populations. The early clinical and laboratory diagnosis of intestinal ischemia remains a challenge. None of the proposed plasma-derived tests for acute mesenteric ischemia has as yet entered routine clinical practice. The proposed biomarkers need to be evaluated in a prospective clinical research project in patients with acute abdomen.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Acute mesenteric ischemia; Plasma markers
- Cardiology
- Kardiologi
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Nilsson, Torbjörn,1956-Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden(Swepub:umu)toni0049 (författare)
- Vaskulära sjukdomar - kliniska studierForskargrupper vid Lunds universitet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of Thrombosis and Thrombolysis: Springer33:4, s. 355-3610929-53051573-742X
Internetlänk
- http://www.ncbi.nlm.nih.gov/pubmed/22081293?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1007/s11239-011-0660-zFULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27904
- https://doi.org/10.1007/s11239-011-0660-z
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79812
- https://lup.lub.lu.se/record/2220785
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- Journal of Thrombosis and Thrombolysis (Sök värdpublikationen i LIBRIS)
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