id:"swepub:oai:DiVA.org:oru-28662"
Search: id:"swepub:oai:DiVA.org:oru-28662" > Early detection of ...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Hörer, Tal,1971-Örebro universitet,Institutionen för hälsovetenskap och medicin (author)
Early detection of major surgical postoperative complications evaluated by microdialysis
- BookEnglish2013
Publisher, publication year, extent ...
- Örebro :Örebro universitet,2013
- 64 s.
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-28662
- ISBN:9789176689394
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-28662URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Series
- Örebro Studies in Medicine,1652-4063 ;89
Notes
- Major abdominal surgery may be followed by postoperative complications, especially in the elderly and patients with co morbidities as diabetes mellitus and obesity. Some of the most feared complications as anastomotic leakage, abdominal infections, abdominal compartment syndrome (ACS) and intestinal ischemia can lead to sepsis, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) with high morbidity and mortality. This thesis evaluates intraperitoneal microdialysis (IPM) as a method for early detection of surgical complications. IPM measures extracellular metabolites as lactate, pyruvate, glycerol and glucose. The lactate/pyruvate (l/p) ratio describes the current relationship between aerobic and anaerobic metabolism. Glycerol is a degradation product of lipolysis from fat and a part of the cell membrane and released when cell injury occurs. In Paper I, evaluation of IPM in patients with and without diabetes mellitus and obesity during 48 hours after abdominal surgery did not show any difference in l/p ratio and glycerol levels compared to a control group. Paper II investigated the first two days after abdominal surgery in patients with major complications using IPM. L/p ratio was higher and glycerol was lower. Paper III used IPM in the immediate postoperative period in patients after endovascular repair for ruptured abdominal aortic aneurysm (rEVAR). Patients who required decompression due to intraabdominal hypertension (IAH) with organ failure had higher l/p ratio and glycerol. Paper IV investigated the effects of Aortic Balloon Occlusion (ABO) and Superior Mesenteric Artery (SMA) occlusion for one hour followed by three hours reperfusion in an animal model. ABO had a pronounced effect on the hemodynamic state. I.p l/p ratio increased during ischemia and decreased on reperfusion while glycerol increased on reperfusion and the effect was less pronounced in the SMA group. In conclusion, IPM monitoring of l/p ratio and glycerol indicates serious postoperative complications at an early stage. The l/p ratio increases or is continuously high while glycerol seems to have a more complex pattern. Diabetes and obesity do not influence the results.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- aortic occlusion balloon
- anastomotic leakage
- glycerol
- intraabdominal hypertension
- intraperitoneal microdialysis
- intestinal ischemia
- intraabdominal metabolism
- lactate/pyruvate ratio
- postoperative complications
- ruptured abdominal aortic anerusym
- Kirurgi
- Surgery
Added entries (persons, corporate bodies, meetings, titles ...)
- Janson, Kjell (thesis advisor)
- Norgren, Lars (thesis advisor)
- Jeppsson, Bengt,ProfessorLunds universitet, Kirurgkliniken (opponent)
- Örebro universitetInstitutionen för hälsovetenskap och medicin (creator_code:org_t)
Internet link
Find in a library
- Early detection of major surgical postoperative complications evaluated by micro... (Search the publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Hörer, Tal, 1971 ...
- Janson, Kjell
- Norgren, Lars
- Jeppsson, Bengt, ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Surgery
- Parts in the series
- Örebro Studies i ...
- By the university
- Örebro University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
