Plasmodium falciparum infection patterns since birth and risk of severe malaria: a nested case-control study in children on the coast of Kenya

Plasmodium falciparum infection patterns since birth and risk of severe malaria : a nested case-control study in children on the coast of Kenya

Children in malaria endemic areas acquire immunity to severe malaria faster than to mild malaria. Only a minority of children suffers from severe malaria and it is not known what determines this. The aim of this study was to establish how P. falciparum infections during the first years of life affect the risk of severe malaria. A matched case-control study was nested within a large birth cohort set up to study the immunoepidemiology of pneumococci on the Kenyan coast. Infection patterns in three-monthly blood samples in cohort children admitted to hospital with severe malaria were compared to controls matched on age, residential location and time of sampling. P. falciparum detected at least once from birth conferred an increased risk of severe malaria and particularly if multiclonal infections, as characterized by genotyping of a polymorphic antigen gene, were ever detected. The results show for the first time that children with severe malaria have more infections early in life compared to community controls. These findings provide important insights on the immunity to severe disease, knowledge essential for the development of a vaccine against severe malaria.

Murungi, LindaCentre for Geographical Medicine Research (Coast), Kilifi, Kenya (författare)
Nyaga, VictoriaCentre for Geographical Medicine Research (Coast), Kilifi, Kenya (författare)
Olsson, DanielKarolinska Institutet (författare)
Rono, JoseaKarolinska Institute, Stockholm, Sweden; Geographical Medicine Research (Coast), Kilifi, Kenya (författare)
Osier, FaithCentre for Geographical Medicine Research (Coast), Kilifi, Kenya (författare)
Ogada, EdnaCentre for Geographical Medicine Research (Coast), Kilifi, Kenya (författare)
Montgomery, ScottKarolinska Institutet,Örebro universitet,Hälsoakademin,Region Örebro County, Örebro, Sweden(Swepub:oru)smy (författare)
Scott, J. Anthony G.Churchill Hospital, University of Oxford, Oxford, United Kingdom (författare)
Marsh, KevinCentre for Geographical Medicine Research (Coast), Kilifi, Kenya (författare)
Färnert, AnnaKarolinska Institutet (författare)
Karolinska InstitutetCentre for Geographical Medicine Research (Coast), Kilifi, Kenya (creator_code:org_t)

Av författaren/redakt...: Lundblom, Klara; Murungi, Linda; Nyaga, Victoria; Olsson, Daniel; Rono, Josea; Osier, Faith; visa fler...; Ogada, Edna; Montgomery, Scot ...; Scott, J. Anthon ...; Marsh, Kevin; Färnert, Anna; visa färre...

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