WFRF:(Rask Eva 1958 )
Sökning: WFRF:(Rask Eva 1958 ) > Axelson M > Cortisol metabolism...
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- Rask, Eva,1958-Department of Medicine, Örebro University Hospital, Örebro, Sweden (författare)
Cortisol metabolism after weight loss : associations with 11 beta-HSD type 1 and markers of obesity in women
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
- 2013-04-10
- Wiley,2013
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-29044
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-29044URI
- https://doi.org/10.1111/j.1365-2265.2012.04333.xDOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-71078URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:126556003URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Objective Increased glucocorticoid metabolite excretion and enhanced expression and activity of 11-hydroxysteroid dehydrogenase type 1 in adipose tissue are closely correlated with obesity and its detrimental consequences. Weight loss ameliorates the latter. The aim of this study was to explore whether increased glucocorticoid exposure in obesity is improved with substantial weight loss and thus is a consequence rather than a cause of obesity.Design and patients A prospective cohort study in 31 women.Measurements 11-HSD type 1 expression and activity, urinary glucocorticoid metabolite excretion, body composition including regional adipose tissue depots and insulin resistance by HOMA-IR before and 2years after gastric bypass surgery.Results After weight loss, excretion of cortisol and cortisone metabolites decreased. Both cortisol and cortisone metabolite excretion correlated with central obesity, where the intraabdominal fat depot showed the strongest association. Cortisol metabolites correlated with 11-HSD type 1 activity in abdominal subcutaneous adipose tissue. The ratio of cortisol to cortisone metabolites [(5-tetrahydrocortisol (5THF)+tetrahydrocortisol (THF)+-cortol)/(tetrahydrocortisone (THE)+-cortolone)] and the ratio of 5-THF/THF both decreased after stable weight loss, reflecting a downregulation of the net activities of 11-HSD type 1 and 5-reductase.Conclusion Long-term weight loss in women is not only followed by reduced glucocorticoid production, but also favourably decreases the global and tissue-specific activity of the cortisol-activating enzyme 11 -HSD type 1, possibly contributing to the health benefits of bariatric surgery.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- Medicine
- Medicin
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Simonyte, KotrynaUmeå universitet,Medicin(Swepub:umu)kosi0001 (författare)
- Lonn, L.Rigshospitalet, Copenhagen, Denmark (författare)
- Axelson, M.Karolinska Institutet (författare)
- Department of Medicine, Örebro University Hospital, Örebro, SwedenMedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Clinical Endocrinology: Wiley78:5, s. 700-7050300-06641365-2265
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