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Variations in folat...
Variations in folate pathway genes are associated with unexplained female infertility
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- Altmae, Signe (författare)
- Karolinska Institutet,Div Obstet & Gynecol,Karolinska Inst, Stockholm, Sweden; Dept Clin Sci Intervent & Technol, Huddinge Hosp, Karolinska Univ, Huddinge, Sweden
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- Stavreus-Evers, Anneli (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson,Dept Womens & Childrens Hlth, Akad Sjukhuset, Uppsala Univ, Uppsala, Sweden
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- Ruiz, Jonatan R. (författare)
- Karolinska Institutet,Dept Biosci & Nutr, Unit Prevent Nutr, Karolinska Inst, Stockholm, Sweden
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- Laanpere, Margit (författare)
- Inst Mol & Cell Biol, Dept Biotechnol, Univ Tartu, Tartu, Estonia
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- Syvanen, Tiina (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson,Dept Womens & Childrens Hlth, Akad Sjukhuset, Uppsala Univ, Uppsala, Sweden
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- Yngve, Agneta, 1953- (författare)
- Karolinska Institutet,Dept Biosci & Nutr, Karolinska Inst, Stockholm, Sweden
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- Salumets, Andres (författare)
- Inst Mol & Cell Biol, Dept Biotechnol, Univ Tartu, Tartu, Estonia; Dept Obstet & Gynecol, Univ Tartu, Tartu, Estonia
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- Nilsson, Torbjörn K (författare)
- Dept Clin Chem, Orebro Univ Hosp, Orebro, Sweden,Department of Clinical Chemistry, Örebro University Hospital,Dept of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 94:1, s. 130-137
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: To investigate associations between folate-metabolizing gene variations, folate status, and unexplained female infertility. Design: An association study. Setting: Hospital-based IVF unit and university-affiliated reproductive research laboratories. Patient(s): Seventy-one female patients with unexplained infertility. Intervention(s): Blood samples for polymorphism genotyping and homocysteine, vitamin B12, and folate measurements. Main Outcome Measure(s): Allele and genotype frequencies of the following polymorphisms: 5,10-methylenetetra-hydrofolate reductase (MTHFR) 677C/T, 1298A/C, and 1793G/A, folate receptor 1 (FOLR1) 1314G/A, 1816delC, 1841G/A, and 1928C/T, transcobalamin II (TCN2) 776C/G, cystathionase (CTH) 1208G/T and solute carrier family 19, member 1 (SLC19A1) 80G/A, and concentrations of plasma homocysteine, vitamin B12, and serum folate. Result(s): MTHFR genotypes 677CT and 1793GA, as well as 1793 allele A were significantly more frequent among controls than in patients. The common MTHFR wild-type haplotype (677, 1298, 1793) CAG was less prevalent, whereas the rare haplotype CCA was more frequent in the general population than among infertility patients. The frequency of SLC19A1 80G/A genotypes differed significantly between controls and patients and the A allele was more common in the general population than in infertile women. Plasma homocysteine concentrations were influenced by CTH 1208G/T polymorphism among infertile women. Conclusion(s): Polymorphisms in folate pathway genes could be one reason for fertility complications in some women with unexplained infertility. (Fertil Steril (R) 2010;94:130-7. (C) 2010 by American Society for Reproductive Medicine.)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Female infertility
- homocysteine
- MTHFR
- FOLR1
- TCN2
- CTH
- SLC19A1
- Nutrition
- Näringslära
- Måltidskunskap
- Culinary Arts and Meal Science
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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