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Analysis of single ...
Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease
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- Soderman, Jan (författare)
- Ryhov County Hospital, Sweden
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- Noren, Elisabeth (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Ryhov County Hospital, Sweden
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- Christiansson, Malin (författare)
- Ryhov County Hospital, Sweden
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- Bragde, Hanna, 1979- (författare)
- Ryhov County Hospital, Sweden
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- Thiebaut, Raphaele (författare)
- University of Paris Diderot, France University of Paris Diderot Sorbonne Paris Cite, France
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- Hugot, Jean-Pierre (författare)
- University of Paris Diderot, France University of Paris Diderot Sorbonne Paris Cite, France Hop Robert Debre, France
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- Tysk, Curt (författare)
- Örebro universitet,Hälsoakademin,Örebro University, Sweden Örebro Uni, Sweden
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- O'Morain, Colm A. (författare)
- Adelaide and Meath Hospital, Ireland Trinity Coll Dublin, Ireland
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- Gassull, Miquel (författare)
- Health Science Research Institute, Spain
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- Finkel, Yigael (författare)
- Karolinska Institutet
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- Colombel, Jean-Frederic (författare)
- Hop Calmette, France Icahn School Medical Mt Sinai, NY 10029 USA
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- Lemann, Marc (författare)
- Hop St Louis, France
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- Almer, Sven (författare)
- Karolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Magtarmmedicinska kliniken
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(creator_code:org_t)
- Baishideng Publishing Group Inc. 2013
- 2013
- Engelska.
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Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327 .- 2219-2840. ; 19:30, s. 4935-4943
- Relaterad länk:
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https://doi.org/10.3...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- AIM: To investigate a possible genetic influence of claudin (CLDN) 1, CLDN2 and CLDN4 in the etiology of inflammatory bowel disease.METHODS: Allelic association between genetic regions of CLDN1, CLDN2 or CLDN4 and patients with inflammatory bowel disease, Crohn's disease (CD) or ulcerative colitis were investigated using both a case-control study approach (one case randomly selected from each of 191 Swedish inflammatory bowel disease families and 333 controls) and a family-based study (463 non-Swedish European inflammatory bowel disease-families). A nonsynonymous coding single nucleotide polymorphism in MORC4, located on the same linkage block as CLDN2, was investigated for association, as were two novel CLDN2 single nucleotide polymorphism markers, identified by resequencing.RESULTS: A single nucleotide polymorphism marker (rs12014762) located in the genetic region of CLDN2 was significantly associated to CD (case-control allelic OR = 1.98, 95% CI: 1.17-3.35, P = 0.007). MORC4 was present on the same linkage block as this CD marker. Using the case-control approach, a significant association (case control allelic OR = 1.61, 95% CI: 1.08-2.41, P = 0.018) was found between CD and a nonsynonymous coding single nucleotide polymorphism (rs6622126) in MORC4. The association between the CLDN2 marker and CD was not replicated in the family-based study. Ulcerative colitis was not associated to any of the single nucleotide polymorphism markers.CONCLUSION: These findings suggest that a variant of the CLDN2-MORC4 region predisposes to CD in a Swedish population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Crohn's disease
- Genetic predisposition
- Inflammatory bowel disease
- Single nucleotide polymorphism
- Tight junctions
- Medicine
- Medicin
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Soderman, Jan
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Noren, Elisabeth
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Christiansson, M ...
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Bragde, Hanna, 1 ...
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Thiebaut, Raphae ...
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Hugot, Jean-Pier ...
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Tysk, Curt
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O'Morain, Colm A ...
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Gassull, Miquel
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Finkel, Yigael
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Colombel, Jean-F ...
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Lemann, Marc
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Almer, Sven
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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World Journal of ...
- Av lärosätet
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Örebro universitet
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Linköpings universitet
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Karolinska Institutet