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Fibre type-specific...
Fibre type-specific satellite cell content in two models of muscle disease
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- Bankole, Landry-Cyrille, 1970- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,University of Lyon, Saint- Etienne, France; University Hospital of Saint-Etienne, Saint- Etienne, France
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- Feasson, Leonard (författare)
- University of Lyon, Saint- Etienne, France; University Hospital of Saint-Etienne, Saint- Etienne, France
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- Ponsot, Elodie, 1973- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,RISPA
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- Kadi, Fawzi, 1970- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,RISPA- MEP-RG
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(creator_code:org_t)
- 2013-09-20
- 2013
- Engelska.
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Ingår i: Histopathology. - : Wiley. - 0309-0167 .- 1365-2559. ; 63:6, s. 826-832
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims: Muscle satellite cells (SCs) are responsible for the regenerative events following muscle fibre injury. This study aimed to improve our understanding of SC behaviour in two models of muscle disorder with different pathological mechanisms and onset of disease.Methods and results: Pax7(+)SC content was assessed in types I and II fibres of patients with Duchenne muscular dystrophy (DMD; n=9; age 132years), polymyositis/dermatomyositis (PM/DM; n=9; age 52 +/- 12years) and in controls (n=5; age 26 +/- 5years). Pax7(+)SCs number in type I and II fibres was higher (P<0.05) in DMD and in PM/DM compared to controls. Type I fibres were associated with a higher number of Pax7(+)SCs compared to type II fibres only in DMD; Pax7(+)SCs number in type I fibres was about threefold higher in DMD compared to PM/DM (P<0.05). In DMD, Pax7(+)SC content in small regenerating fibres (0.09 +/- 0.09 SCs/fibre) was similar to that in fibres from healthy skeletal muscle. The proportion of activated SCs (Ki-67(+)SCs) was fivefold lower in DMD (0.4 +/- 0.4%) compared to PM/DM (2.8 +/- 2%). Pax7(+) cells located outside the basal lamina were observed in DMD muscles only.Conclusion: The capacity to generate new SCs is increased even in severely impaired muscles and a fibre type-specific enhancement of SC occurs in type I muscle fibres in DMD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Duchenne muscular dystrophy
- Pax7
- polymyositis and dermatomyositis
- regeneration
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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