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Axillary recurrence...
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Bergkvist, LeifUppsala universitet,Centrum för klinisk forskning, Västerås
(författare)
Axillary recurrence rate after negative sentinel node biopsy in breast cancer : three-year follow-up of the Swedish Multicenter Cohort Study
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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Lippincott Williams & Wilkins,2008
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-3422
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3422URI
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https://doi.org/10.1097/SLA.0b013e318153ff40DOI
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https://lup.lub.lu.se/record/1200246URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:116366274URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-95905URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Sentinel lymph node biopsy is an established staging method in early breast cancer. After a negative biopsy, most institutions will not perform a completion axillary dissection. The present study reports the current axillary recurrence (AR) rate, overall and disease-free survival in the Swedish Multicenter Cohort Study.Methods: From 3534 patients with primary breast cancer ≤3 cm prospectively enrolled in the Swedish multicenter cohort study, 2246 with a negative sentinel node biopsy and no further axillary surgery were selected. Follow-up consisted of annual clinical examination and mammography. Twenty-six hospitals and 131 surgeons contributed to patient accrual.Results: After a median follow-up time of 37 months (0-75), the axilla was the sole initial site of recurrence in 13 patients (13 of 2246, 0.6%). In another 7 patients, axillary relapse occurred after or concurrently with a local recurrence in the breast, and in a further 7 cases, it coincided with distant or extra-axillary lymphatic metastases. Thus, a total of 27 ARs were identified (27 of 2246, 1.2%). The overall 5-year survival was 91.6% and disease-free survival 92.1%.Conclusions: This is the first report from a national multicenter study that covers, not only highly specialized institutions but also small community hospitals with just a few procedures per year. Despite this heterogeneous background, the results lie well within the range of AR rates published internationally (0%-3.6%). The sentinel node biopsy procedure seems to be safe in a multicenter setting. Nevertheless, long-term follow-up data should be awaited before firm conclusions are drawn.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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de Boniface, JanaUppsala universitet,Centrum för klinisk forskning, Västerås
(författare)
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Jönsson, Per-EbbeLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)med-pej
(författare)
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Ingvar, ChristianLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-cin
(författare)
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Liljegren, GöranÖrebro universitet,Hälsoakademin(Swepub:oru)gnln
(författare)
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Frisell, JanKarolinska Institutet
(författare)
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Uppsala universitetCentrum för klinisk forskning, Västerås
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annals of Surgery: Lippincott Williams & Wilkins247:1, s. 150-1560003-49321528-1140
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