WFRF:(Särndahl Eva 1963 )
Search: WFRF:(Särndahl Eva 1963 ) > Human Gene Variants...
- 28 of 72
- Previous record
- Next record
- To hitlist
- Eklund, Daniel,1984-Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet (author)
Human Gene Variants Linked to Enhanced NLRP3 Activity Limit Intramacrophage Growth of Mycobacterium tuberculosis
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2013-10-24
- Cary, USA :Oxford University Press,2014
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-34504
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-34504URI
- https://doi.org/10.1093/infdis/jit572DOI
- https://gup.ub.gu.se/publication/187599URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100889URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Funding Agency:Swedish Research Council Bill and Melinda Gates FoundationSwedish Heart-Lung Foundation Carl Trygger Foundation
- Activation of the NLRP3 inflammasome and subsequent generation of interleukin 1 beta is initiated in macrophages upon recognition of several stimuli. In the present work, we show that gain-of-function gene variants of inflammasome components known to predispose individuals to inflammatory disorders have a host-protective role during infection with Mycobacterium tuberculosis. By isolation of macrophages from patients and healthy blood donors with genetic variants in NLRP3 and CARD8 and subsequent infection of the cells with virulent M. tuberculosis, we show that these gene variants, combined, are associated with increased control of bacterial growth in human macrophages.
Subject headings and genre
- NATURVETENSKAP Biologi Immunologi hsv//swe
- NATURAL SCIENCES Biological Sciences Immunology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- NLRP3
- CARD8
- inflammasome
- IL-1 beta
- human macrophage
- C10X
- Q705K
- tuberculosis
- mycobacteria
- Immunologi
- Immunology
- NLRP3
- CARD8
- inflammasome
- IL-1β
- human macrophage
- C10X
- Q705K
- tuberculosis
- mycobacteria
Added entries (persons, corporate bodies, meetings, titles ...)
- Welin, Amanda,1983Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)amawe34 (author)
- Andersson, HenrikLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)henan81 (author)
- Verma, DeeptiLinköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet(Swepub:liu)deeve22 (author)
- Söderkvist, PeterÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik(Swepub:liu)petso43 (author)
- Stendahl, OlleLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)ollst48 (author)
- Särndahl, Eva,1963-Linköpings universitet,Örebro universitet,Institutionen för läkarutbildning,Avdelningen för cellbiologi,Hälsouniversitetet(Swepub:liu)evasa98 (author)
- Lerm, MariaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)marle69 (author)
- Linköpings universitetAvdelningen för mikrobiologi och molekylär medicin (creator_code:org_t)
Related titles
- In:Journal of Infectious DiseasesCary, USA : Oxford University Press209:5, s. 749-7530022-18991537-6613
Internet link
- https://doi.org/10.1093/infdis/jit572Fulltext
- https://academic.oup.com/jid/article-pdf/209/5/749/13804619/jit572.pdf
- https://liu.diva-portal.org/smash/get/diva2:664167/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-34504
- https://doi.org/10.1093/infdis/jit572
- https://gup.ub.gu.se/publication/187599
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100889
Find in a library
- Journal of Infectious Diseases (Search for host publication in LIBRIS)
To the university's database
- 28 of 72
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Eklund, Daniel, ...
- Welin, Amanda, 1 ...
- Andersson, Henri ...
- Verma, Deepti
- Söderkvist, Pete ...
- Stendahl, Olle
- show more...
- Särndahl, Eva, 1 ...
- Lerm, Maria
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Immunology
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Microbiology in ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- Articles in the publication
- Journal of Infec ...
- By the university
- Örebro University
- University of Gothenburg
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
