Home sampling and pooling of vaginal samples are effective tools for genetic screening of Chlamydia trachomatis among high school female students in Lithuania

The aims were 1) to estimate the prevalence of C. trachomatis infection among sexually active female students in Kaunas, Lithuania; 2) to investigate the usefulness of personal invitation, self-sampling, and pooling of samples for screening; and 3) to evaluate the costs of the approaches used. A cross-sectional study inviting 795 female students (18–31 y of age) from 7 high schools and 1 college in Kaunas was performed. The response rate was 67% (533/795). Self-obtained vaginal samples were analysed, individually and pooled (n=3), using Digene Hybrid Capture II CT/NG Test. The overall prevalence of C. trachomatis infection was 5.6%. Among the sexually active female students 20–24 y of age (n=424), the prevalence was 7.1%; however, the prevalence varied from 0% to 14.2% at the different schools. For estimation of the population prevalence based solely on identification of C. trachomatis positive pools, the pooling strategy reduced the costs by 85%. For estimation of population prevalence and for diagnosis of each individual sample, pooling reduced the costs by 70%. Targeted screening, using pooling to reduce the expenses, mainly of 3rd and 4th y Lithuanian female students could be recommended. By extended personal contact and internet-based communication, increased participation rates may be attained.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
Adolescent
Adult
Chlamydia Infections/*diagnosis/epidemiology
Chlamydia trachomatis/genetics/isolation & purification
Cost-Benefit Analysis
Female
Humans
Lithuania/epidemiology
Mass Screening/*methods
Oligonucleotide Array Sequence Analysis
Prevalence
Self Care/*methods
Sexual Behavior
Specimen Handling
Students
Vaginal Diseases/*diagnosis/epidemiology/microbiology
Vaginal Smears/methods
MEDICINE
MEDICIN
Dermatology and venerology
Dermatologi och venerologi
Dermatology and Venerology
Dermatologi och venereologi

Juseviciute, Violeta (författare)
Valiukeviciene, Skaidra (författare)
Milasauskiene, Zemyna (författare)
Unemo, MagnusÖrebro universitet,Hälsoakademin(Swepub:oru)muo (författare)
Domeika, MariusUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)maridome (författare)
Örebro universitetHälsoakademin (creator_code:org_t)

Ingår i:Scandinavian Journal of Infectious DiseasesLondon : Taylor & Francis40:2, s. 88-930036-55481651-1980

Av författaren/redakt...: Kucinskiene, Ves ...; Juseviciute, Vio ...; Valiukeviciene, ...; Milasauskiene, Z ...; Unemo, Magnus; Domeika, Marius

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Dermatologi och ...

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