Risk of thromboembolism in 14,000 individuals with coeliac disease

Ludvigsson, Jonas F.Karolinska Institutet,Örebro universitet,Hälsoakademin (författare)

The risk of venous thromboembolism (VTE) was examined in individuals with coeliac disease (CD). The Swedish national inpatient register was used to identify 14 207 individuals with a diagnosis of CD (1964–2003). These individuals were matched for age, sex, calendar year and county with 69 048 reference individuals. Cox regression was used to estimate hazard ratios (HRs) for subsequent thromboembolism in individuals with more than 1 year of follow-up and no prior VTE. CD was associated with an increased risk of subsequent VTE (HR = 1·86; 95% confidence interval (CI) 1·54–2·24). The risk increase was restricted to individuals with CD diagnosed in adulthood. Risk estimates were not affected by the presence of diabetes mellitus or concomitant surgery. Compared with inpatients as reference individuals, CD individuals remained at increased risk of subsequent VTE (adjusted HR = 1·27; 95% CI = 1·06–1·52). In conclusion, this study found a statistically significantly positive association between CD and VTE. This modest association might be explained by a combination of surveillance bias and chronic inflammation

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Adolescent
Adult
Age Factors
Case-Control Studies
Celiac Disease/*complications
Child
Child; Preschool
Female
Follow-Up Studies
Humans
Male
Middle Aged
Proportional Hazards Models
Registries
Risk Assessment/methods
Risk Factors
Sex Factors
Sweden
Thromboembolism/*etiology
MEDICINE
MEDICIN
Cardiovascular medicine
Kardiovaskulär medicin
Epidemiology
Epidemiologi
Epidemiologi
Epidemiology

Welander, AdinaKarolinska Institutet (författare)
Lassila, Riitta (författare)
Ekbom, AndersKarolinska Institutet (författare)
Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Hälsoakademin(Swepub:oru)smy (författare)
Örebro universitetHälsoakademin (creator_code:org_t)

Ingår i:British Journal of Haematology: Wiley139:1, s. 121-1270007-10481365-2141

Av författaren/redakt...: Ludvigsson, Jona ...; Welander, Adina; Lassila, Riitta; Ekbom, Anders; Montgomery, Scot ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

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