Time-dependent relative potency factors for polycyclic aromatic hydrocarbons and their derivatives in the H4IIE-luc bioassay

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Larsson, Maria,1975-Örebro universitet,Institutionen för naturvetenskap och teknik (författare)

Time-dependent relative potency factors for polycyclic aromatic hydrocarbons and their derivatives in the H4IIE-luc bioassay

Artikel/kapitelEngelska2014

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2014-02-26
Hoboken :Wiley-Blackwell,2014
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LIBRIS-ID:oai:DiVA.org:oru-34942
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-34942URI
https://doi.org/10.1002/etc.2517DOI

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Språk:engelska
Sammanfattning på:engelska

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Funding Agencies:Canada Research Chair ProgramDepartment of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong KongState Administration of Foreign Experts Affairs, the People's Republic of China to Nanjing UniversityEinstein Professor Program of the Chinese Academy of Sciences
The H4IIE-luc transactivation bioassay for aryl hydrocarbon receptor (AhR) agonists was used to investigate the relative potency factors (REPs) of 22 individual polycyclic aromatic hydrocarbons (PAHs) and their oxygenated-, methylated-, and N-containing derivatives (azaarenes), which are often present in PAH-contaminated soils. Naphthacene and dibenz[ah]acridine exhibited greater AhR-mediated potency, whereas lesser molecular-weight azaarenes were less potent AhR agonists. Six oxygenated PAHs had calculable REPs, but their potencies were less than their parent PAHs. Unlike the parent, unsubstituted PAHs, oxidation of methylated PAHs seemed to increase the AhR-mediated potency of the compounds, with 2-methylanthracene-9,10-dione being almost 2 times more potent than 2-methylanthracene. Both bioassay and gas chromatography-mass spectrometry analysis were used to examine the exposure time-dependent effects on the REPs at 24 h, 48 h, and 72 h of exposure in the H4IIE-luc transactivation bioassay. Changes in concentrations of 5 compounds including the model reference 2,3,7,8-tetrachlorodibenzo-p-dioxin in the cell culture wells were measured, and the amounts in the cell medium, in the cells, and adsorbed to the wells was determined and the influence on the REPs was studied. Declining REP values with increased duration of exposure were shown for all compounds, which we concluded were a consequence of the metabolism of PAHs and PAH derivatives in H4IIe-luc cells. The present study provides new knowledge regarding the degradation and distribution of compounds in the wells during exposure. Environ Toxicol Chem 2014;33:943-953. (c) 2014 SETAC

Ämnesord och genrebeteckningar

NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
Soils
Toxic equivalents
In vitro Toxicology
Monitoring
Polycyclic aromatic compounds (PAHs)
Organic contaminants
Enviromental Science
Miljövetenskap

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hagberg, Jessika,1974-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)jahg (författare)
Giesy, John P.Dept Vet Biomed Sci, Univ Saskatchewan, Saskatoon SK, Canada; Toxicol Ctr, Univ Saskatchewan, Saskatoon SK, Canada; Dept Zool, Michigan State Univ, E Lansing, USA; Ctr Integrat Toxicol, Michigan State Univ, E Lansing, USA; Dept Biol & Chem, City Univ Hong Kong, Kowloon, Peoples R China; State Key Lab Marine Pollut, City Univ Hong Kong, Kowloon, Peoples R China; Sch Biol Sci, Univ Hong Kong, Hong Kong, Peoples R China; Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing Univ, Nanjing, Peoples R China (författare)
Engwall, Magnus,1965-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)mel (författare)
Örebro universitetInstitutionen för naturvetenskap och teknik (creator_code:org_t)

Sammanhörande titlar

Ingår i:Environmental Toxicology and ChemistryHoboken : Wiley-Blackwell33:4, s. 943-9530730-72681552-8618

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