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Coeliac disease and...
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Ludvigsson, Jonas F.Karolinska Institutet,Örebro universitet,Hälsoakademin
(författare)
Coeliac disease and the risk of fractures : a general population-based cohort study
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2006-12-19
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Oxford :Blackwell Scientific,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-3496
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3496URI
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https://doi.org/10.1111/j.1365-2036.2006.03203.xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-24332URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:12307629URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Earlier studies have suggested that untreated coeliac disease may be associated with osteoporosis, but results are contradictory for the risk of long-term fractures.Aim: To study the association between coeliac disease and fractures.Methods: We used Cox regresson to examine the future risk of hip fracture and fracture of any type in more than 13 000 individuals with coeliac disease and 65 000 age- and sex-matched reference individuals in a general population-based cohort.Results: During follow-up, 1365 first hip fractures and 4847 fractures of any type occurred. Coeliac disease was positively associated with subsequent hip fracture (hazard ratio = 2.1; 95% CI = 1.8-2.4) (in children: hazard ratio = 2.6; 95% CI = 1.1-6.2) and fractures of any type (hazard ratio = 1.4; 95% CI = 1.3-1.5) (in children: hazard ratio = 1.1; 95% CI = 1.0-1.2). The absolute excess risk of hip fractures in children with coeliac disease was 4/100 000 person-years. Incidence ratios for hip fracture in individuals with CD were around two both prior to diagnosis of coeliac disease and afterwards; this risk increase remained 20 years after diagnosis of coeliac disease.Conclusions: Individuals with coeliac disease, including children with coeliac disease, may be at increased risk of hip fracture and fracture of any type. Coeliac disease may be positively associated with long-term hip fracture risk.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Michaëlsson, KarlUppsala universitet,Ortopedi(Swepub:uu)karlmich
(författare)
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Ekbom, A.Karolinska Institutet
(författare)
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Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Hälsoakademin,Clinical Research Centre, Örebro University Hospital(Swepub:oru)smy
(författare)
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Örebro universitetHälsoakademin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Alimentary Pharmacology and TherapeuticsOxford : Blackwell Scientific25:3, s. 273-2850269-28131365-2036
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