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SPOP Mutations in P...
SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts
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- Blattner, Mirjam (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York, USA
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- Lee, Daniel J. (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York, USA
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- O'Reilly, Catherine (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA
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- Park, Kyung (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA
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- MacDonald, Theresa Y. (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA
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- Khani, Francesca (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA
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- Turner, Kevin R. (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA
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- Chiu, Ya-Lin (författare)
- Dept Biostat & Epidemiol, Weill Med Coll, Cornell Univ, New York NY, USA
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- Wild, Peter J. (författare)
- Inst Surg Pathol, Univ Zurich Hosp, Zurich, Switzerland
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- Dolgalev, Igor (författare)
- Human Oncol & Pathogenesis Program, Mem Sloan Kettering Canc Ctr, New York NY, USA
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- Heguy, Adriana (författare)
- Human Oncol & Pathogenesis Program, Mem Sloan Kettering Canc Ctr, New York NY, USA
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- Sboner, Andrea (författare)
- Dept Pathol & Lab Med, Inst Precis Med, New York NY, USA; Weill Med Coll, Cornell Univ, Inst Computat Biomed, New York, NY, USA; Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA
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- Ramazangolu, Sinan (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Inst Computat Biomed, Weill Med Coll, Cornell Univ, New York NY, USA
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- Hieronymus, Haley (författare)
- Inst Computat Biomed, Weill Med Coll, Cornell Univ, New York NY, USA
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- Sawyers, Charles (författare)
- Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York NY, USA
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- Tewari, Ashutosh K. (författare)
- Dept Urol, Weill Med Coll, Cornell Univ, New York NY, USA
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- Moch, Holger (författare)
- Inst Surg Pathol, Univ Zurich Hosp, Zurich, Switzerland
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- Yoon, Ghil Suk (författare)
- Sch Med, Dept Pathol, Kyungpook Natl Univ, Taegu, South Korea
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- Known, Yong Chul (författare)
- Sch Med, Dept Pathol, Catholic Univ Daegu, Taegu, South Korea
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- Andrén, Ove, 1963- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Dept Urol, Örebro University Hospital, Örebro, Sweden
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- Fall, Katja, 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Demichelis, Francecsa (författare)
- Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Ctr Integrat Biol, Univ Trento, Trento, Italy
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- Mosquera, Juan Miguel (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA
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- Robinson, Brian D. (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York NY, USA
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- Barbieri, Christopher E. (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York NY, USA
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- Rubin, Mark A. (författare)
- Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York NY, USA; Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA
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(creator_code:org_t)
- New York : Elsevier, 2014
- 2014
- Engelska.
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Ingår i: Neoplasia. - New York : Elsevier. - 1522-8002 .- 1476-5586. ; 16:1, s. 14-U34
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Recurrent mutations in the Speckle-Type POZ Protein (SPOP) gene occur in up to 15% of prostate cancers. However, the frequency and features of cancers with these mutations across different populations is unknown.OBJECTIVE: To investigate SPOP mutations across diverse cohorts and validate a series of assays employing high-resolution melting (HRM) analysis and Sanger sequencing for mutational analysis of formalin-fixed paraffin-embedded material.DESIGN, SETTING, AND PARTICIPANTS: 720 prostate cancer samples from six international cohorts spanning Caucasian, African American, and Asian patients, including both prostate-specific antigen-screened and unscreened populations, were screened for their SPOP mutation status. Status of SPOP was correlated to molecular features (ERG rearrangement, PTEN deletion, and CHD1 deletion) as well as clinical and pathologic features.RESULTS AND LIMITATIONS: Overall frequency of SPOP mutations was 8.1% (4.6% to 14.4%), SPOP mutation was inversely associated with ERG rearrangement (P < .01), and SPOP mutant (SPOPmut) cancers had higher rates of CHD1 deletions (P < .01). There were no significant differences in biochemical recurrence in SPOPmut cancers. Limitations of this study include missing mutational data due to sample quality and lack of power to identify a difference in clinical outcomes.CONCLUSION: SPOP is mutated in 4.6% to 14.4% of patients with prostate cancer across different ethnic and demographic backgrounds. There was no significant association between SPOP mutations with ethnicity, clinical, or pathologic parameters. Mutual exclusivity of SPOP mutation with ERG rearrangement as well as a high association with CHD1 deletion reinforces SPOP mutation as defining a distinct molecular subclass of prostate cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- RADICAL RETROPUBIC PROSTATECTOMY; MELTING ANALYSIS; SURVIVAL RATES; EFFICIENT; TMPRSS2; FUSION
- Onkologi
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Blattner, Mirjam
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Lee, Daniel J.
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O'Reilly, Cather ...
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Park, Kyung
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MacDonald, There ...
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Khani, Francesca
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visa fler...
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Turner, Kevin R.
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Chiu, Ya-Lin
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Wild, Peter J.
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Dolgalev, Igor
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Heguy, Adriana
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Sboner, Andrea
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Ramazangolu, Sin ...
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Hieronymus, Hale ...
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Sawyers, Charles
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Tewari, Ashutosh ...
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Moch, Holger
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Yoon, Ghil Suk
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Known, Yong Chul
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Andrén, Ove, 196 ...
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Fall, Katja, 197 ...
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Demichelis, Fran ...
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Mosquera, Juan M ...
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Robinson, Brian ...
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Barbieri, Christ ...
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Rubin, Mark A.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Neoplasia
- Av lärosätet
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Örebro universitet