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  • Blattner, MirjamDept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York, USA (author)

SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • New York :Elsevier,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-35221
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35221URI
  • https://doi.org/10.1593/neo.131704DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:National Cancer Institute 1RO1CA125612  5UO1CA11275Prostate Cancer FoundationSystemsX.ch grant (PhosphoNet-PPM)Prostate Cancer Foundation Young Investigator AwardUrology Care Foundation Research Scholar Award
  • BACKGROUND: Recurrent mutations in the Speckle-Type POZ Protein (SPOP) gene occur in up to 15% of prostate cancers. However, the frequency and features of cancers with these mutations across different populations is unknown.OBJECTIVE: To investigate SPOP mutations across diverse cohorts and validate a series of assays employing high-resolution melting (HRM) analysis and Sanger sequencing for mutational analysis of formalin-fixed paraffin-embedded material.DESIGN, SETTING, AND PARTICIPANTS: 720 prostate cancer samples from six international cohorts spanning Caucasian, African American, and Asian patients, including both prostate-specific antigen-screened and unscreened populations, were screened for their SPOP mutation status. Status of SPOP was correlated to molecular features (ERG rearrangement, PTEN deletion, and CHD1 deletion) as well as clinical and pathologic features.RESULTS AND LIMITATIONS: Overall frequency of SPOP mutations was 8.1% (4.6% to 14.4%), SPOP mutation was inversely associated with ERG rearrangement (P < .01), and SPOP mutant (SPOPmut) cancers had higher rates of CHD1 deletions (P < .01). There were no significant differences in biochemical recurrence in SPOPmut cancers. Limitations of this study include missing mutational data due to sample quality and lack of power to identify a difference in clinical outcomes.CONCLUSION: SPOP is mutated in 4.6% to 14.4% of patients with prostate cancer across different ethnic and demographic backgrounds. There was no significant association between SPOP mutations with ethnicity, clinical, or pathologic parameters. Mutual exclusivity of SPOP mutation with ERG rearrangement as well as a high association with CHD1 deletion reinforces SPOP mutation as defining a distinct molecular subclass of prostate cancer.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lee, Daniel J.Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York, USA (author)
  • O'Reilly, CatherineDept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Park, KyungDept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • MacDonald, Theresa Y.Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Khani, FrancescaDept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Turner, Kevin R.Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Chiu, Ya-LinDept Biostat & Epidemiol, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Wild, Peter J.Inst Surg Pathol, Univ Zurich Hosp, Zurich, Switzerland (author)
  • Dolgalev, IgorHuman Oncol & Pathogenesis Program, Mem Sloan Kettering Canc Ctr, New York NY, USA (author)
  • Heguy, AdrianaHuman Oncol & Pathogenesis Program, Mem Sloan Kettering Canc Ctr, New York NY, USA (author)
  • Sboner, AndreaDept Pathol & Lab Med, Inst Precis Med, New York NY, USA; Weill Med Coll, Cornell Univ, Inst Computat Biomed, New York, NY, USA; Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Ramazangolu, SinanDept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Inst Computat Biomed, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Hieronymus, HaleyInst Computat Biomed, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Sawyers, CharlesMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York NY, USA (author)
  • Tewari, Ashutosh K.Dept Urol, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Moch, HolgerInst Surg Pathol, Univ Zurich Hosp, Zurich, Switzerland (author)
  • Yoon, Ghil SukSch Med, Dept Pathol, Kyungpook Natl Univ, Taegu, South Korea (author)
  • Known, Yong ChulSch Med, Dept Pathol, Catholic Univ Daegu, Taegu, South Korea (author)
  • Andrén, Ove,1963-Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Dept Urol, Örebro University Hospital, Örebro, Sweden(Swepub:oru)oan (author)
  • Fall, Katja,1971-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)kafl (author)
  • Demichelis, FrancecsaInst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Ctr Integrat Biol, Univ Trento, Trento, Italy (author)
  • Mosquera, Juan MiguelDept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Robinson, Brian D.Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Barbieri, Christopher E.Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Rubin, Mark A.Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York NY, USA; Inst Precis Med, Weill Med Coll, Cornell Univ, New York NY, USA (author)
  • Dept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York, USADept Pathol & Lab Med, Inst Precis Med, Weill Med Coll, Cornell Univ, New York, USA; Dept Urol, Weill Med Coll, Cornell Univ, New York, USA (creator_code:org_t)

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