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Increased prevalenc...
Increased prevalence of HTLV-1 in patients with pulmonary tuberculosis coinfected with HIV, but not in HIV-negative patients with tuberculosis
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- Norrgren, Hans (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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Bamba, Sana (author)
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Larsen, Olav (author)
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Da Silva, Zacarias (author)
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Aaby, Peter (author)
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- Koivula, Tuija (author)
- Karolinska Institutet
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- Andersson, Sören (author)
- Örebro universitet,Hälsoakademin
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(creator_code:org_t)
- Philadelphia, PA : Lippincott Williams & Wilkins, 2008
- 2008
- English.
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In: Journal of Acquired Immune Deficiency Syndromes. - Philadelphia, PA : Lippincott Williams & Wilkins. - 1525-4135 .- 1944-7884. ; 48:5, s. 607-610
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Abstract
Subject headings
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- Background: Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB). Methods: In 1994-1997, we performed a prospective study on hospitalized adult patients with pulmonary TB in Guinea-Bissau and compared the clinical outcome in HIV-2 and HIV-negative patients. We determined the prevalence of HTLV-1 in all patients screened and diagnosed with TB in that study and compared the infection rate with a serosurvey of HTLV-1 in a population sample from a community-based study conducted at the same time and in the same city. Results: In the TB group, a total of 32 (11.4%) of 280 patients were positive for HTLV-1. This was significantly higher compared with the population-based group in which 74 (3.5%) of 2117 were HTLV-1 positive [crude odds ratio (OR) = 3.6; 95% confidence interval (CI) 2.2 to 5.6, P < 0.001]. However, in a logistic regression analysis controlling for age, gender, and HIV result, the difference was no longer significant (OR = 1.61; 95% CI 0.95 to 2.70, P = 0.074). In HIV-negative patients, no association was found between HTLV-1 and TB (OR = 1.18; 95% CI 0.48 to 2.89, P = 0.71), whereas a significant association was found in HIV-positive patients (OR = 2.41; 95% CI 1.26 to 4.61, P = 0.008). Conclusions: The immunosuppressive effect of HTLV-1 alone was not enough to increase the risk of TB in a highly endemic country, but HTLV-1 increased the risk of TB among HIV-infected individuals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- Adult
- Female
- HIV Infections/*complications/epidemiology/virology
- HIV-1/isolation & purification
- HIV-2/isolation & purification
- HTLV-I Antibodies/*blood
- HTLV-I Infections/complications/*epidemiology/virology
- Human T-lymphotropic virus 1/isolation & purification
- Humans
- Logistic Models
- Male
- Middle Aged
- Prevalence
- Prospective Studies
- Tuberculosis; Pulmonary/*complications/epidemiology
- MEDICINE
- MEDICIN
- Microbiology
- Mikrobiologi
- Virology
- Virologi
- Microbiology
- Mikrobiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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