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Cytokine profile in...
Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome
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- Sahdo, Berolla, 1984- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University, Sweden
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- Fransén, Karin, 1973- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University, Sweden
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- Asfaw Idosa, Berhane, 1977- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University, Sweden
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- Eriksson, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland
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- Söderquist, Bo, 1955- (author)
- Örebro universitet,Institutionen för läkarutbildning,Örebro University Hospital, Region Örebro County, Örebro, Sweden
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- Kelly, Anne, 1978- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University Hospital and Örebro University, Sweden
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- Särndahl, Eva, 1963- (author)
- Örebro universitet,Institutionen för läkarutbildning,Örebro University, Sweden
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(creator_code:org_t)
- 2013-10-03
- 2013
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:10
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https://liu.diva-por... (primary) (Raw object)
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Abstract
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- Background: The NLRP3 inflammasome has been recognized as one of the key components of the innate immunity by sensing a diversity of insults. Inflammasome activation results in the maturation of the pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18. Increased production of IL-1 beta is found in patients with gain-of-function polymorphisms in genes encoding the NLRP3 inflammasome. Since approximately 5% of the Swedish population are heterozygote carriers of these combined gene variants, their impact on inflammasome status and a relationship on disease development is therefore highly relevant to study. The present study investigates levels of inflammasome-produced cytokines as a measure of inflammasome activation in healthy individuals carrying Q705K polymorphism in the NLRP3 gene combined with C10X in the CARD8 gene.Materials and Methods: Genotyping of 1006 healthy blood donors was performed for the polymorphisms Q705K in the NLRP3 and C10X in the CARD8 genes. IL-1 beta, IL-18, IL-33, as well as a number of other pro-inflammatory cytokines, were analyzed by Luminex or ELISA in plasma from individuals carrying the polymorphisms and in age and gender matched non-carrier controls.Results & Discussion: The prevalence of the polymorphisms was in line with previous studies. Plasma levels of IL-1 beta and IL-33 were elevated among carriers of combined Q705K+C10X polymorphisms compared to controls, whereas no difference was found for IL-18 and the other cytokines measured. Moreover, carriers of C10X or Q705K per se had similar plasma levels of IL-1 beta as non-carriers. These data suggest that the combined polymorphisms create inflammasomes with increased basal activation state, which might provide a more favourable innate immune response. In spite of this, it could also represent the mechanisms by which the inflammatory loop is triggered into a long-term inflammatory phenotype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sahdo, Berolla, ...
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Fransén, Karin, ...
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Asfaw Idosa, Ber ...
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Eriksson, Per
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Söderquist, Bo, ...
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Kelly, Anne, 197 ...
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Särndahl, Eva, 1 ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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PLOS ONE
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Örebro University
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Linköping University