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Low gut microbiota ...
Low gut microbiota diversity in early infancy precedes asthma at school age
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- Abrahamsson, Thomas (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Jakobsson, H. E. (författare)
- Dept Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, Sweden,Karolinska Institute, Stockholm, Sweden
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- Andersson, Anders F. (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Sch Biotechnol, Div Gene Technol, Sci Life Lab, Royal Inst Technol (KTH ), Stockholm, Sweden,KTH Royal Institute of Technology, Stockholm, Sweden
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- Björkstén, Bengt, 1940- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Karolinska Institute, Stockholm, Sweden; Örebro University, Sweden
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- Engstrand, Lars (författare)
- Karolinska Institutet,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Dept Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, Sweden; Div Gene Technol, Sci Life Lab, KTH Royal Inst Technol, Sch Biotechnol, Stockholm, Sweden,Karolinska Institute, Stockholm, Sweden; KTH Royal Institute of Technology, Stockholm, Sweden
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- Jenmalm, Maria (författare)
- Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet
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(creator_code:org_t)
- 2014-05-24
- 2014
- Engelska.
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 44:6, s. 842-850
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Abstract
Ämnesord
Stäng
- Background Low total diversity of the gut microbiota during the first year of life is associated with allergic diseases in infancy, but little is known how early microbial diversity is related to allergic disease later in school age. Objective To assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to the prevalence of different allergic diseases in school age, such as asthma, allergic rhinoconjunctivitis (ARC) and eczema. Methods The microbial diversity and composition was analysed with barcoded 16S rDNA 454 pyrosequencing in stool samples at 1week, 1month and 12months of age in 47 infants which were subsequently assessed for allergic disease and skin prick test reactivity at 7years of age (ClinicalTrials.gov ID NCT01285830). Results Children developing asthma (n=8) had a lower diversity of the total microbiota than non-asthmatic children at 1week (P=0.04) and 1month (P=0.003) of age, whereas allergic rhinoconjunctivitis (n=13), eczema (n=12) and positive skin prick reactivity (n=14) at 7years of age did not associate with the gut microbiota diversity. Neither was asthma associated with the microbiota composition later in infancy (at 12months). Children having IgE-associated eczema in infancy and subsequently developing asthma had lower microbial diversity than those that did not. There were no significant differences, however, in relative abundance of bacterial phyla and genera between children with or without allergic disease. Conclusion and Clinical Relevance Low total diversity of the gut microbiota during the first month of life was associated with asthma but not ARC in children at 7years of age. Measures affecting microbial colonization of the infant during the first month of life may impact asthma development in childhood.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- asthma
- allergic rhinoconjunctivitis
- birth
- children
- diversity
- hygiene hypothesis
- microbiota
- molecular microbiology
- Medicine
- Medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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