Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy

von Beckerath, Mathias P.,1966-Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Dept Otolaryngol & Head & Neck Surg, Örebro University Hospital, Örebro, Sweden (författare)

Conclusion: Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of many sarcomas, PDT appears to be an organ- and function-sparing therapy, although it is more costly than other treatments.Objectives: The aim of this study was to show the results of PDT when it is used as a primary treatment of early laryngeal cancer. Methods: We studied the results of PDT when used as a primary treatment. We looked at survival, effect on tumor, side effects, voice, and costs.Results: The follow-up period was a median of 59 months. Nine of 10 patients were cured of their laryngeal cancer. PDT alone cured seven patients. All four of the sarcomas were cured using temoporfin. Two of three tumors that involved the anterior commissure were cured using only interstitial illumination with PDT. No serious side effects were noted. The patient's voices were improved after treatment in 5 of 10 cases, and none had a worsened voice.

Reizenstein, Johan A.Dept Oncol, Örebro Univ Hosp, Örebro, Sweden (författare)
Berner, Attila L.Dept Otolaryngol & Head & Neck Surg, Örebro Univ Hosp, Örebro, Sweden (författare)
Nordqvist, Kent W. O.Dept Logoped & Phoniatr, Örebro Univ Hosp, Örebro, Sweden (författare)
Landström, Fredrik J.,1966-Örebro universitet,Institutionen för hälsovetenskap och medicin,Dept Otolaryngol & Head & Neck Surg, Örebro Univ Hosp, Örebro, Sweden(Swepub:oru)flm (författare)
Löfgren, Axel Lennart,1939-Örebro universitet,Institutionen för klinisk medicin,Dept Otolaryngol & Head & Neck Surg, Örebro Univ Hosp, Örebro, Sweden(Swepub:oru)ltln (författare)
Möller, Claes,1950-Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Audiology Reseach Center, Örebro University Hospital, Örebro, Sweden(Swepub:oru)cmr (författare)
Örebro universitetInstitutionen för hälsovetenskap och medicin (creator_code:org_t)

Ingår i:Acta Oto-Laryngologica: Informa UK Limited134:8, s. 852-8580001-64891651-2251

Av författaren/redakt...: von Beckerath, M ...; Reizenstein, Joh ...; Berner, Attila L ...; Nordqvist, Kent ...; Landström, Fredr ...; Löfgren, Axel Le ...; visa fler...; Möller, Claes, 1 ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Oto rhino laryng ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.