Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort

• Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Keyword

Aged

Cohort Studies

Gene Expression Profiling/*methods

Humans

Immunoenzyme Techniques

Male

Prostate-Specific Antigen/blood

Prostatic Neoplasms/epidemiology/*metabolism/*mortality

Survival Rate

Tissue Array Analysis

Tumor Markers; Biological/*metabolism

MEDICINE

MEDICIN

Oncology

Onkologi

Urology and andrology

Urologi och andrologi

Onkologi

Oncology

Publication and Content Type

ref (subject category)

art (subject category)