Experimental vitreous tamponade using polyalkylimide hydrogel

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MARC

Crafoord, SvenDepartments of Ophthalmology, Örebro University Hospital, Örebro, Sweden (author)

Experimental vitreous tamponade using polyalkylimide hydrogel

Article/chapterEnglish2011

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2011-03-31
Springer Science and Business Media LLC,2011
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LIBRIS-ID:oai:DiVA.org:oru-37220
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37220URI
https://doi.org/10.1007/s00417-011-1652-6DOI
https://lup.lub.lu.se/record/2162979URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding agencies:- Faculty of Medicine, University of Lund - Swedish Research Council - Torsten and Ragnar Soderberg Foundation - Departments of Ophthalmology Orebro University Hospital
PURPOSE: To evaluate polyalkylimide as a possible vitreous tamponading agent.METHODS: A 20-gauge pars plana vitrectomy and posterior vitreous detachment were performed in the right eye of six pigmented rabbits. Approximately 1 ml of viscoelastic gel, polyalkylimide (Bio-Alcamid) was thereafter injected into the vitreous space. Full-field ERG and intraocular pressure (IOP, Tonopen) was measured pre-and postoperatively at regular intervals up to 28 days. At day 6 or 28, the rabbits were sacrificed and the eyes were examined macroscopically, photographed, and prepared for histological examination with routine microscopy.RESULTS: The viscoelastic hydrogel was successfully injected, and remained translucent with preserved gel properties throughout the postoperative period. The postoperative IOP was unchanged compared to preoperative values. Five of six eyes displayed retinal edema or pigmentary changes centrally while the periphery appeared intact. ERG recordings showed a radical decrease in rod- and cone-derived B-wave amplitudes. Histological examination confirmed varying degrees of edema combined with neuronal cell death within the retinal layers in the central part of the fundus, while the peripheral part appeared intact.CONCLUSION: Polyalkylimide displays favourable physical properties when used as a vitreous tamponade. However, the hydrogel causes functional and morphological retinal damage when in direct contact with the inner retina. Possible pathological mechanisms include osmotic imbalance and direct toxic effects, and modification of biochemical properties is warranted before clinical use will be possible.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oftalmologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Ophthalmology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Vitreous. Vitrectomy
Photoreceptor death
Surgery
Kirurgi
Vitreous
Vitrectomy
Photoreceptor death

Added entries (persons, corporate bodies, meetings, titles ...)

Andréasson, StenLund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)oft-san (author)
Ghosh, FredrikLund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)oft-fgh (author)
Departments of Ophthalmology, Örebro University Hospital, Örebro, SwedenOftalmologi, Lund (creator_code:org_t)

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In:Graefe's Archives for Clinical and Experimental Ophthalmology: Springer Science and Business Media LLC249:8, s. 1167-740721-832X1435-702X

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By the author/editor: Crafoord, Sven; Andréasson, Sten; Ghosh, Fredrik

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Ophthalmology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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