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Increased risk of p...
Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis
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- Bergquist, Annika (författare)
- Karolinska Institutet,Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institute, Huddinge and Solna, Stockholm
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- Montgomery, Scott M. (författare)
- Karolinska Institutet,Örebro universitet,Hälsoakademin,Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Stockholm, Clinical Research Centre, Örebro University Hospital, Örebro
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- Bahmanyar, Shahram (författare)
- Karolinska Institutet,Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Stockholm
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- Olsson, Rolf (författare)
- Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Danielsson, Åke (författare)
- Umeå universitet,Medicin,Danielsson, Å., Department of Medicine, Section for Gastroenterology and Hepatology, University Hospital, Umeå
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- Lindgren, Stefan (författare)
- Lund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups,Department of Gastroenterology and Hepatology, University Hospital, Malmö,Lööf, L.A.R.S., Centre for Clinical Research, Central Hospital, Västerås
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- Prytz, Hanne (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Gastroenterology and Hepatology, University Hospital, Lund
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- Hultcrantz, Rolf (författare)
- Karolinska Institutet,Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institute, Huddinge and Solna, Stockholm
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- Lööf, Lars (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Sandberg-Gertzén, Hanna (författare)
- Sandberg-Gertzén, H., Division of Gastroenterology and Hepatology, Department of Medicine, Medical Center Hospital, Örebro
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- Almer, Sven (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Gastroenterologi och hepatologi,Endokrin- och magtarmmedicinska kliniken US
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- Askling, Johan (författare)
- Karolinska Institutet,Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Stockholm
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- Ehlin, Anna (författare)
- Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Stockholm
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- Ekbom, Anders (författare)
- Karolinska Institutet,Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Stockholm
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(creator_code:org_t)
- New York : Elsevier, 2008
- 2008
- Engelska.
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Ingår i: Clinical Gastroenterology and Hepatology. - New York : Elsevier. - 1542-3565 .- 1542-7714. ; 6:8, s. 939-943
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background & Aims: The importance of genetic factors for the development of primary sclerosing cholangitis (PSC) is incompletely understood. This study assessed the risk of PSC and inflammatory bowel disease (IBD) among first-degree relatives of patients with PSC, compared with the first-degree relatives of a cohort without PSC. Methods: Subjects from the national Swedish cohort of PSC patients (n = 678) were matched for date of birth, sex, and region to up to 10 subjects without a diagnosis of PSC (n = 6347). Linkage through general population registers identified first-degree relatives of subjects in both the PSC and comparison cohorts (n = 34,092). Diagnoses among first-degree relatives were identified by using the Inpatient Register. Results: The risk of cholangitis was statistically significantly increased in offspring, siblings, and parents of the PSC patient cohort, compared with relatives of the comparison cohort, with the hazard ratios and 95% confidence intervals, 11.5 (1.6–84.4), 11.1 (3.3–37.8), and 2.3 (0.9–6.1), respectively. The hazard ratios for ulcerative colitis (UC) among first-degree relatives of all PSC patients was 3.3 (2.3–4.9) and for Crohn's disease 1.4 (0.8–2.5). The risk of UC for relatives of PSC patients without IBD was also increased, 7.4 (2.9–18.9). Conclusions: First-degree relatives of patients with PSC run an increased risk of PSC, indicating the importance of genetic factors in the etiology of PSC. First-degree relatives of PSC patients without IBD are also at an increased risk of UC, which might indicate shared genetic susceptibility factors for PSC and UC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Case-Control Studies
- Child of Impaired Parents
- Cholangitis; Sclerosing/*epidemiology
- Colitis; Ulcerative/*epidemiology
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Sweden
- MEDICINE
- MEDICIN
- Internal medicine
- Invärtesmedicin
- Gastroenterology
- Gastroenterologi
- Medicine
- Medicin
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Bergquist, Annik ...
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Montgomery, Scot ...
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Bahmanyar, Shahr ...
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Olsson, Rolf
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Danielsson, Åke
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Lindgren, Stefan
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Prytz, Hanne
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Hultcrantz, Rolf
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Lööf, Lars
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Sandberg-Gertzén ...
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Almer, Sven
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Askling, Johan
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Ehlin, Anna
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Ekbom, Anders
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Örebro universitet
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Karolinska Institutet
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