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Autologous haematop...
Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis : the Swedish experience
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- Burman, Joachim (author)
- Uppsala universitet,Neurologi,Uppsala University, Sweden; University of Uppsala Hospital, Sweden
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- Iacobaeus, Ellen (author)
- Karolinska Institutet
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- Svenningsson, Anders (author)
- Umeå universitet,Klinisk neurovetenskap
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- Lycke, Jan (author)
- Department of Neurology, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Gunnarsson, Martin, 1973- (author)
- Örebro universitet,Institutionen för läkarutbildning,Department of Neurology, Örebro University Hospital, Örebro, Sweden
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- Nilsson, Petra (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital Lund, Sweden
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- Vrethem, Magnus (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neurovetenskap,Hälsouniversitetet,Neurologiska kliniken
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- Fredrikson, Sten (author)
- Karolinska Institutet
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- Martin, Claes (author)
- Karolinska Institutet
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- Sandstedt, Anna (author)
- Linköpings universitet,Institutionen för samhälls- och välfärdsstudier,Hälsouniversitetet
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- Uggla, Bertil, 1962- (author)
- Örebro universitet,Institutionen för läkarutbildning,Region Örebro län,Division of Hematology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Lenhoff, Stig (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden
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- Johansson, Jan-Erik, 1946- (author)
- Department of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Isaksson, Cecilia (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Hägglund, Hans (author)
- Karolinska Institutet,Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden
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- Carlson, Kristina (author)
- Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden
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- Fagius, Jan (author)
- Uppsala universitet,Neurologi,Uppsala University, Sweden; University of Uppsala Hospital, Sweden
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(creator_code:org_t)
- 2014-02-19
- 2014
- English.
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In: Journal of Neurology, Neurosurgery and Psychiatry. - London, United Kingdom : BMJ Publishing Group Ltd. - 0022-3050 .- 1468-330X. ; 85:10, s. 1116-1121
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background: Autologous haematopoietic stem cell transplantation (HSCT) is a viable option for treatment of aggressive multiple sclerosis (MS). No randomised controlled trial has been performed, and thus, experiences from systematic and sustained follow-up of treated patients constitute important information about safety and efficacy. In this observational study, we describe the characteristics and outcome of the Swedish patients treated with HSCT for MS.Methods: Neurologists from the major hospitals in Sweden filled out a follow-up form with prospectively collected data. Fifty-two patients were identified in total; 48 were included in the study and evaluated for safety and side effects; 41 patients had at least 1 year of follow-up and were further analysed for clinical and radiological outcome. In this cohort, 34 patients (83%) had relapsing-remitting MS, and mean follow-up time was 47 months.Results: At 5 years, relapse-free survival was 87%; MRI event-free survival 85%; expanded disability status scale (EDSS) score progression-free survival 77%; and disease-free survival (no relapses, no new MRI lesions and no EDSS progression) 68%. Presence of gadolinium-enhancing lesions prior to HSCT was associated with a favourable outcome (disease-free survival 79% vs 46%, p=0.028). There was no mortality. The most common long-term side effects were herpes zoster reactivation (15%) and thyroid disease (8.4%).Conclusions: HSCT is a very effective treatment of inflammatory active MS and can be performed with a high degree of safety at experienced centres.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Neurologi
- Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Burman, Joachim
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Iacobaeus, Ellen
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Svenningsson, An ...
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Lycke, Jan
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Gunnarsson, Mart ...
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Nilsson, Petra
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show more...
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Vrethem, Magnus
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Fredrikson, Sten
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Martin, Claes
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Sandstedt, Anna
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Uggla, Bertil, 1 ...
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Lenhoff, Stig
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Johansson, Jan-E ...
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Isaksson, Cecili ...
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Hägglund, Hans
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Carlson, Kristin ...
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Fagius, Jan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Journal of Neuro ...
- By the university
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Örebro University
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet
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Umeå University