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  • Halfvarson, JonasDivision of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, Sweden (author)

Environmental factors in inflammatory bowel disease : a co-twin control study of a Swedish-Danish twin population

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Oxford University Press (OUP),2006
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-3786
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3786URI
  • https://doi.org/10.1097/01.mib.0000228998.29466.acDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:112372908URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-37491URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND:Genetics and environmental factors are implicated in the etiology of inflammatory bowel disease (IBD). We studied environmental factors in a population-based Swedish-Danish twin cohort using the co-twin control method.SUBJECTS AND METHODS:A questionnaire was sent to 317 twin pairs regarding markers of exposures in the following areas: infections/colonization and diet as well as smoking, appendectomy, and oral contraceptives. Odds ratios (OR) were calculated by conditional logistic regression. When confounding appeared plausible, multivariate conditional logistic regression was added. The questions were also divided into topic groups, and adjustment was made for multiple testing within each of the groups.RESULTS:The response rate to the questionnaire was 83%. In consideration of the study design, only discordant pairs were included (Crohn's disease [CD], n = 102; ulcerative colitis [UC], n = 125). Recurrent gastrointestinal infections were associated with both UC (OR, 8.0; 95% confidence interval [CI], 1.0-64) and CD (OR, 5.5; 95% CI, 1.2-25). Hospitalization for gastrointestinal infections was associated with CD (OR, 12; 95% CI, 1.6-92). Smoking was inversely associated with UC (OR, 0.4; 95% CI, 0.2-0.9) and associated with CD (OR, 2.9; 95% CI, 1.2-7.1).CONCLUSIONS:The observed associations indicate that markers of possible infectious events may influence the risk of IBD. Some of these effects might be mediated by long-term changes in gut flora or alterations in reactivity to the flora. The influence of smoking in IBD was confirmed.

Subject headings and genre

  • Adult
  • Aged
  • Aged 80 and over
  • Appendectomy/statistics & numerical data
  • Bacterial Infections/epidemiology
  • Case-Control Studies
  • Colitis Ulcerative/epidemiology/etiology
  • Contraceptives Oral/adverse effects
  • Crohn Disease/epidemiology/etiology
  • Denmark/epidemiology
  • Diet/adverse effects
  • Diseases in Twins/epidemiology/etiology
  • Female
  • Humans
  • Inflammatory Bowel Diseases/*epidemiology/*etiology
  • Male
  • Middle Aged
  • Motor Activity
  • Population Surveillance
  • Risk Factors
  • Smoking/adverse effects
  • Sweden/epidemiology
  • MEDICINE
  • MEDICIN
  • Medicine
  • Medicin

Added entries (persons, corporate bodies, meetings, titles ...)

  • Jess, TineDepartment of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark (author)
  • Magnuson, AndersStatistical and Epidemiological Unit, Clinical Research Centre, Örebro University Hospital, Örebro, Sweden (author)
  • Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Institutionen för klinisk medicin,Statistical and Epidemiological Unit, Clinical Research Centre, Örebro University Hospital, Örebro, Sweden(Swepub:oru)smy (author)
  • Orholm, MarianneDepartment of Internal Medicine, Elsinore Hospital, Elsinore, Denmark (author)
  • Tysk, CurtÖrebro universitet,Institutionen för klinisk medicin,Division of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, Sweden and Department of Clinical Medicine, Örebro University, Örebro, Sweden(Swepub:oru)ctk (author)
  • Binder, VibekeDepartment of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark (author)
  • Järnerot, GunnarDivision of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, Sweden (author)
  • Division of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, SwedenDepartment of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark (creator_code:org_t)

Related titles

  • In:Inflammatory Bowel Diseases: Oxford University Press (OUP)12:10, s. 925-9331078-09981536-4844

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