Perinatal events and the risk of developing primary sclerosing cholangitis

AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life.METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC.RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively. CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily be explained, so our findings do not strongly support the hypothesis of a significant role of perinatal events as a risk for the development of PSC later in life.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Adult
Breast Feeding
Cholangitis
Sclerosing/*etiology/physiopathology
Edema/complications/physiopathology
Female
Humans
Labor
Obstetric/physiology
Logistic Models
Pregnancy
Pregnancy Complications
Prenatal Exposure Delayed Effects
Retrospective Studies
Risk Factors
Uterine Hemorrhage/complications/physiopathology
MEDICINE
MEDICIN
Internal medicine
Invärtesmedicin
Gastroenterology
Gastroenterologi
Medicine
Medicin
inflammatory bowel disease
perinatal factors
sclerosing cholangitis

Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Institutionen för klinisk medicin(Swepub:oru)smy (författare)
Lund, UlrikaKarolinska Institutet (författare)
Ekbom, AndersKarolinska Institutet (författare)
Olsson, Rolf (författare)
Lindgren, StefanLund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups(Swepub:lu)medf-sli (författare)
Prytz, HanneLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-hpr (författare)
Hultcrantz, RolfKarolinska Institutet (författare)
Broomé, Ulrika (författare)
Karolinska InstitutetInstitutionen för klinisk medicin (creator_code:org_t)

Ingår i:World Journal of Gastroenterology: Baishideng Publishing Group Inc.12:37, s. 6037-60401007-93272219-2840

Av författaren/redakt...: Bergquist, Annik ...; Montgomery, Scot ...; Lund, Ulrika; Ekbom, Anders; Olsson, Rolf; Lindgren, Stefan; visa fler...; Prytz, Hanne; Hultcrantz, Rolf; Broomé, Ulrika; visa färre...

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